PDF(Pubmed)
Abstract：
UNASSIGNED: Vestibular migraine (VM), an intricate subtype of migraine, amalgamates the dual attributes of migraine and vestibular disorders. In clinical settings, individuals with VM frequently articulate concerns regarding the manifestation of subjective cognitive impairment. This cognitive dysfunction is intricately linked with diminished mobility, heightened susceptibility to falls, and increased absenteeism in afflicted patients. Consequently, comprehending the features of cognitive impairment in VM patients holds potential clinical significance. The pursuit of rapid and objective methods for detection and assessment is foundational and prerequisite for efficacious cognitive management of VM patients.
UNASSIGNED: The study encompassed 50 patients diagnosed with vestibular migraine and recruited 50 age-sex matched healthy controls. All participants underwent anti-saccade tasks, and cognitive evaluation was performed using the MMSE and MoCA to assess overall cognitive function. Additionally, RBANS scales were employed to measure specific cognitive domains.
UNASSIGNED: The VM patients and normal controls demonstrated statistical parity in terms of age, gender, education, weight, and BMI, with no significant differences observed. Analysis of cognitive scores divulged a marked increase in the incidence of Mild Cognitive Impairment (MCI) in VM patients compared to Healthy Controls (HCs). Both MMSE and MoCA scores were notably lower in VM patients compared to their healthy counterparts. The RBANS cognitive test indicated significant impairment in immediate memory, visuospatial construction, language, attention, and delayed memory among VM patients. Notably, the Trail Making Test and Stroop Color-Word Test revealed compromised processing speed and executive function cognitive domains. The anti-saccadic task highlighted significantly elevated anti-saccadic latency and frequency of direction errors in vestibular migraine patients. Symptom severity, illness duration, and episode frequency in VM patients positively correlated with counter-scanning errors and negatively correlated with cognitive performance across diverse cognitive domains.
UNASSIGNED: VM patients exhibit cognitive decline across multiple cognitive domains during the interictal period. This cognitive impairment may not be fully reversible, underscoring its potential clinical significance for cognitive management in VM patients. The sensitivity of anti-saccade tasks to the cognitive status of VM patients positions them as promising objective indicators for diagnosis, intervention, and evaluation of cognitive impairment effects in VM in future applications.
UNASSIGNED: The study encompassed 50 patients diagnosed with vestibular migraine and recruited 50 age-sex matched healthy controls. All participants underwent anti-saccade tasks, and cognitive evaluation was performed using the MMSE and MoCA to assess overall cognitive function. Additionally, RBANS scales were employed to measure specific cognitive domains.
UNASSIGNED: The VM patients and normal controls demonstrated statistical parity in terms of age, gender, education, weight, and BMI, with no significant differences observed. Analysis of cognitive scores divulged a marked increase in the incidence of Mild Cognitive Impairment (MCI) in VM patients compared to Healthy Controls (HCs). Both MMSE and MoCA scores were notably lower in VM patients compared to their healthy counterparts. The RBANS cognitive test indicated significant impairment in immediate memory, visuospatial construction, language, attention, and delayed memory among VM patients. Notably, the Trail Making Test and Stroop Color-Word Test revealed compromised processing speed and executive function cognitive domains. The anti-saccadic task highlighted significantly elevated anti-saccadic latency and frequency of direction errors in vestibular migraine patients. Symptom severity, illness duration, and episode frequency in VM patients positively correlated with counter-scanning errors and negatively correlated with cognitive performance across diverse cognitive domains.
UNASSIGNED: VM patients exhibit cognitive decline across multiple cognitive domains during the interictal period. This cognitive impairment may not be fully reversible, underscoring its potential clinical significance for cognitive management in VM patients. The sensitivity of anti-saccade tasks to the cognitive status of VM patients positions them as promising objective indicators for diagnosis, intervention, and evaluation of cognitive impairment effects in VM in future applications.
摘要：
■前庭性偏头痛（VM），一种复杂的偏头痛亚型,合并偏头痛和前庭疾病的双重属性。在临床环境中，患有VM的个体经常表达对主观认知障碍表现的担忧。这种认知功能障碍与行动能力下降有着错综复杂的联系，更容易跌倒，患病患者的旷工增加。因此,了解VM患者认知障碍的特征具有潜在的临床意义。追求快速和客观的检测和评估方法是有效的VM患者认知管理的基础和先决条件。
■该研究包括50名诊断为前庭偏头痛的患者，并招募了50名年龄性别匹配的健康对照。所有参与者都接受了反扫视任务，使用MMSE和MoCA进行认知评估以评估总体认知功能。此外,RBANS量表用于测量特定的认知领域。
■VM患者和正常对照者在年龄方面表现出统计学上的均等，性别,教育,体重,BMI,没有观察到显著差异。认知评分的分析显示，与健康对照（HC）相比，VM患者中轻度认知损害（MCI）的发生率显着增加。与健康患者相比，VM患者的MMSE和MoCA评分均明显较低。RBANS认知测验显示即时记忆明显受损，视觉空间结构，语言,注意,和VM患者的延迟记忆。值得注意的是,TrailMaking测试和StroopColor-Word测试显示，处理速度和执行功能认知领域受损。抗扫视任务突出了前庭偏头痛患者的抗扫视潜伏期和方向错误频率的显着提高。症状严重程度,疾病持续时间,VM患者的发作频率与反扫描错误呈正相关，而与不同认知领域的认知表现呈负相关。
■VM患者在发作间期出现跨多个认知域的认知衰退。这种认知障碍可能不是完全可逆的，强调其对VM患者认知管理的潜在临床意义。抗扫视任务对VM患者认知状态的敏感性将其定位为有希望的诊断客观指标。干预，并在未来的应用中评估VM中的认知障碍效应。
■该研究包括50名诊断为前庭偏头痛的患者，并招募了50名年龄性别匹配的健康对照。所有参与者都接受了反扫视任务，使用MMSE和MoCA进行认知评估以评估总体认知功能。此外,RBANS量表用于测量特定的认知领域。
■VM患者和正常对照者在年龄方面表现出统计学上的均等，性别,教育,体重,BMI,没有观察到显著差异。认知评分的分析显示，与健康对照（HC）相比，VM患者中轻度认知损害（MCI）的发生率显着增加。与健康患者相比，VM患者的MMSE和MoCA评分均明显较低。RBANS认知测验显示即时记忆明显受损，视觉空间结构，语言,注意,和VM患者的延迟记忆。值得注意的是,TrailMaking测试和StroopColor-Word测试显示，处理速度和执行功能认知领域受损。抗扫视任务突出了前庭偏头痛患者的抗扫视潜伏期和方向错误频率的显着提高。症状严重程度,疾病持续时间,VM患者的发作频率与反扫描错误呈正相关，而与不同认知领域的认知表现呈负相关。
■VM患者在发作间期出现跨多个认知域的认知衰退。这种认知障碍可能不是完全可逆的，强调其对VM患者认知管理的潜在临床意义。抗扫视任务对VM患者认知状态的敏感性将其定位为有希望的诊断客观指标。干预，并在未来的应用中评估VM中的认知障碍效应。
