PDF(Pubmed)
Abstract：
Proliferation and differentiation of intestinal stem cell (ISC) to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation. However, when this disordered proliferation continues, it induces the ISC to enter a cancerous state. The gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained basis. Microbiota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors, while in steady state, differentiated colonocytes are able to break down such metabolites, thereby protecting stem cells at the gut crypt. In the future, the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.
摘要：
肠干细胞（ISC）在炎症状态下取代受损的肠粘膜上皮细胞的增殖和分化是改善肠道炎症的关键步骤。然而,当这种无序的扩散继续时，它诱导ISC进入癌变状态。肠粘膜屏障的自由表面上的肠微生物群能够持续地与ISC相互作用。微生物代谢产物能够通过转录因子调节肠道干细胞和祖细胞的增殖,当处于稳定状态时，分化的结肠细胞能够分解这些代谢物，从而保护肠道隐窝的干细胞。在未来,肠道菌群及其代谢产物介导ISC分化的调节将是一种潜在的肠道疾病治疗方法。
