PDF(Pubmed)
Abstract：
BACKGROUND: Neonatal sepsis is defined as an infection-related condition characterized by signs and symptoms of bacteremia within the first month of life. It is the leading cause of mortality and morbidity among newborns. While several studies have been conducted in other parts of world to assess the usefulness of complete blood count parameters and hemogram-derived markers as early screening tools for neonatal sepsis, the associations between sepsis and its complications with these blood parameters are still being investigated in our setting and are not yet part of routine practice.
OBJECTIVE: To evaluate the diagnostic significance of complete blood cell count hemogram-derived novel markers for neonatal sepsis among neonates attending public hospitals in the southwest region of Oromia, Ethiopia, through a case control study.
METHODS: A case control study was conducted from October 2021 to October 2023 Sociodemographic, clinical history, and laboratory test results data were collected using structured questionnaires. The collected data were entered into Epi-data 3.1 version and exported to SPSS-25 for analysis. Chi-square, independent sample t-test, and receiver operator characteristics curve of curve were used for analysis. A P-value of less than 0.05 was considered statistically significant.
RESULTS: In this study, significant increases were observed in the following values in the case group compared to the control group: In white blood cell (WBC) count, neutrophils, monocyte, mean platelet volume (MPV), neutrophils to lymphocyte ratio, monocyte to lymphocyte ratio (MLR), red blood cell width to platelet count ratio (RPR), red blood width coefficient variation, MPV to RPR, and platelet to lymphocyte ratio. Regarding MLR, a cut-off value of ≥ 0.26 was found, with a sensitivity of 68%, a specificity of 95%, a positive predictive value (PPV) of 93.2%, and a negative predictive value (NPV) of 74.8%. The area under the curve (AUC) was 0.828 (P < 0.001). For WBC, a cut-off value of ≥ 11.42 was identified, with a sensitivity of 55%, a specificity of 89%, a PPV of 83.3%, and a NPV of 66.4%. The AUC was 0.81 (P < 0.001). Neutrophils had a sensitivity of 67%, a specificity of 81%, a PPV of 77.9%, and a NPV of 71.1%. The AUC was 0.801, with a cut-off value of ≥ 6.76 (P = 0.001). These results indicate that they were excellent predictors of neonatal sepsis diagnosis.
CONCLUSIONS: The findings of our study suggest that certain hematological parameters and hemogram-derived markers may have a potential role in the diagnosis of neonatal sepsis.
OBJECTIVE: To evaluate the diagnostic significance of complete blood cell count hemogram-derived novel markers for neonatal sepsis among neonates attending public hospitals in the southwest region of Oromia, Ethiopia, through a case control study.
METHODS: A case control study was conducted from October 2021 to October 2023 Sociodemographic, clinical history, and laboratory test results data were collected using structured questionnaires. The collected data were entered into Epi-data 3.1 version and exported to SPSS-25 for analysis. Chi-square, independent sample t-test, and receiver operator characteristics curve of curve were used for analysis. A P-value of less than 0.05 was considered statistically significant.
RESULTS: In this study, significant increases were observed in the following values in the case group compared to the control group: In white blood cell (WBC) count, neutrophils, monocyte, mean platelet volume (MPV), neutrophils to lymphocyte ratio, monocyte to lymphocyte ratio (MLR), red blood cell width to platelet count ratio (RPR), red blood width coefficient variation, MPV to RPR, and platelet to lymphocyte ratio. Regarding MLR, a cut-off value of ≥ 0.26 was found, with a sensitivity of 68%, a specificity of 95%, a positive predictive value (PPV) of 93.2%, and a negative predictive value (NPV) of 74.8%. The area under the curve (AUC) was 0.828 (P < 0.001). For WBC, a cut-off value of ≥ 11.42 was identified, with a sensitivity of 55%, a specificity of 89%, a PPV of 83.3%, and a NPV of 66.4%. The AUC was 0.81 (P < 0.001). Neutrophils had a sensitivity of 67%, a specificity of 81%, a PPV of 77.9%, and a NPV of 71.1%. The AUC was 0.801, with a cut-off value of ≥ 6.76 (P = 0.001). These results indicate that they were excellent predictors of neonatal sepsis diagnosis.
CONCLUSIONS: The findings of our study suggest that certain hematological parameters and hemogram-derived markers may have a potential role in the diagnosis of neonatal sepsis.
摘要：
背景：新生儿败血症定义为与感染相关的疾病，其特征是在生命的第一个月内出现菌血症的体征和症状。它是新生儿死亡和发病的主要原因。虽然在世界其他地区已经进行了几项研究，以评估全血细胞计数参数和血象来源的标志物作为新生儿败血症的早期筛查工具的有用性，脓毒症及其并发症与这些血液参数之间的关联仍在我们的研究中,尚未纳入常规治疗.
目的：评估全血细胞计数血象衍生的新型标志物对奥罗米亚西南地区公立医院新生儿败血症的诊断意义。埃塞俄比亚,通过病例对照研究。
方法：2021年10月至2023年10月进行了病例对照研究，临床病史,和实验室检测结果数据使用结构化问卷收集。将收集的数据输入Epi-data3.1版本，并导出到SPSS-25进行分析。卡方，独立样本t检验，并利用曲线的接受者操作者特征曲线进行分析。小于0.05的P值被认为具有统计学意义。
结果：在这项研究中，与对照组相比，在病例组中观察到以下值显着增加：白细胞（WBC）计数，中性粒细胞，单核细胞,平均血小板体积（MPV），中性粒细胞与淋巴细胞的比率，单核细胞与淋巴细胞比率（MLR），红细胞宽度与血小板计数之比（RPR），红细胞宽度变异系数，MPV到RPR,和血小板与淋巴细胞的比率。关于MLR,发现临界值≥0.26，灵敏度为68%,95%的特异性，阳性预测值(PPV)为93.2%，阴性预测值（NPV）为74.8%。曲线下面积(AUC)为0.828(P<0.001)。对于WBC，确定了≥11.42的截止值，灵敏度为55%,特异性为89%，PPV为83.3%，净现值为66.4%。AUC为0.81(P<0.001)。中性粒细胞的敏感性为67%，特异性为81%，PPV为77.9%，净现值为71.1%。AUC为0.801，临界值≥6.76（P=0.001）。这些结果表明，它们是新生儿败血症诊断的出色预测因子。
结论：我们的研究结果表明，某些血液学参数和血象来源的标志物可能在新生儿败血症的诊断中具有潜在作用。
目的：评估全血细胞计数血象衍生的新型标志物对奥罗米亚西南地区公立医院新生儿败血症的诊断意义。埃塞俄比亚,通过病例对照研究。
方法：2021年10月至2023年10月进行了病例对照研究，临床病史,和实验室检测结果数据使用结构化问卷收集。将收集的数据输入Epi-data3.1版本，并导出到SPSS-25进行分析。卡方，独立样本t检验，并利用曲线的接受者操作者特征曲线进行分析。小于0.05的P值被认为具有统计学意义。
结果：在这项研究中，与对照组相比，在病例组中观察到以下值显着增加：白细胞（WBC）计数，中性粒细胞，单核细胞,平均血小板体积（MPV），中性粒细胞与淋巴细胞的比率，单核细胞与淋巴细胞比率（MLR），红细胞宽度与血小板计数之比（RPR），红细胞宽度变异系数，MPV到RPR,和血小板与淋巴细胞的比率。关于MLR,发现临界值≥0.26，灵敏度为68%,95%的特异性，阳性预测值(PPV)为93.2%，阴性预测值（NPV）为74.8%。曲线下面积(AUC)为0.828(P<0.001)。对于WBC，确定了≥11.42的截止值，灵敏度为55%,特异性为89%，PPV为83.3%，净现值为66.4%。AUC为0.81(P<0.001)。中性粒细胞的敏感性为67%，特异性为81%，PPV为77.9%，净现值为71.1%。AUC为0.801，临界值≥6.76（P=0.001）。这些结果表明，它们是新生儿败血症诊断的出色预测因子。
结论：我们的研究结果表明，某些血液学参数和血象来源的标志物可能在新生儿败血症的诊断中具有潜在作用。
