PDF(Pubmed)
Abstract：
UNASSIGNED: Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination. For challenging cases like adenomatous polyps with epithelial misplacement, additional diagnostic methods could prove beneficial.
UNASSIGNED: This paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years.
UNASSIGNED: Both the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes.
UNASSIGNED: This paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years.
UNASSIGNED: Both the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes.
摘要：
■尽管结直肠癌的发病率和死亡率表现出显著的变异性，它仍然是全球最普遍的癌症之一。预防结直肠癌发展的努力集中在结肠镜检查期间检测前体病变。内镜切除的息肉的诊断依赖于苏木精和伊红染色检查。对于有挑战性的病例，如上皮错位的腺瘤性息肉，额外的诊断方法可能被证明是有益的.
■本文旨在强调恶性息肉和假性侵袭息肉中观察到的基质变化，利用双光子激发显微镜（TPEM），近年来在医学领域广泛使用的一种技术。
■TPEM图像的主观和定量分析均显示，与假侵袭区域相比，恶性息肉中侵袭前沿的胶原蛋白分布和密度不同。TPEM具有从假性侵袭中辨别恶性息肉真正侵袭的潜力，提供增强的可视化的局部基质变化。
■本文旨在强调恶性息肉和假性侵袭息肉中观察到的基质变化，利用双光子激发显微镜（TPEM），近年来在医学领域广泛使用的一种技术。
■TPEM图像的主观和定量分析均显示，与假侵袭区域相比，恶性息肉中侵袭前沿的胶原蛋白分布和密度不同。TPEM具有从假性侵袭中辨别恶性息肉真正侵袭的潜力，提供增强的可视化的局部基质变化。
