PDF(Pubmed)
Abstract：
The use of the antimalarial drug hydroxychloroquine is a standard treatment in patients with systemic lupus erythematosus. It helps reduce disease-associated damage, prevents disease flare, and improves overall survival. The mechanism of action of hydroxychloroquine includes interference with lysosomal degradation of cells leading to the accumulation of vacuoles. Retinopathy is a well-described adverse effect of hydroxychloroquine, thus requiring screening with an ophthalmologist after prolonged use. Although rarely reported, cardiac adverse effects of hydroxychloroquine can also occur. In this report, we present a case of a 23-year-old woman with systemic lupus erythematosus on hydroxychloroquine who presented with stroke possibly due to Libman-Sacks endocarditis and was found to have severe hypertrophic cardiomyopathy on transthoracic echocardiogram.
摘要：
使用抗疟药羟氯喹是系统性红斑狼疮患者的标准治疗方法。它有助于减少疾病相关的损害，防止疾病发作，并提高总体生存率。羟氯喹的作用机制包括干扰细胞的溶酶体降解导致液泡的积累。视网膜病变是羟氯喹的良好描述的不良反应，因此需要长期使用后与眼科医生进行筛查。虽然很少报道，羟氯喹的心脏不良反应也可能发生。在这份报告中,我们介绍了一例23岁女性患者,该患者使用羟氯喹治疗,可能是由于Libman-Sacks心内膜炎导致卒中,经胸超声心动图发现患有严重肥厚型心肌病.
