PDF(Pubmed)
Abstract：
This study presents a rare case of an Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) co-existing with medication-related osteonecrosis of the jaw (MRONJ) in the mandible of a 54-year-old Japanese man who complained of painful swelling of the left mandibular gingiva over the past three months. The patient had a history of methotrexate (MTX) and bisphosphonates (BPs) use. Intraoral examination revealed a 35 mm large ulcerative lesion with marginal gingival swelling and bone exposure on the left side of the mandible. A biopsy was performed, confirming the diagnosis of EBVMCU with MRONJ. Due to the enlargement of the bone exposure, marginal resection of the mandible was performed under general anesthesia as a treatment for residual MRONJ. At the two-year follow-up, no evidence of recurrence was observed.
摘要：
这项研究介绍了一例罕见的案例，即爱泼斯坦-巴尔病毒阳性的粘膜皮肤溃疡（EBVMCU）与下颌骨药物相关的骨坏死（MRONJ）共存于54岁的日本男子的下颌骨中，他抱怨疼痛。过去三个月的左下颌牙龈肿胀。患者有甲氨蝶呤（MTX）和双膦酸盐（BPs）使用史。口内检查显示35毫米大的溃疡性病变，下颌骨左侧边缘牙龈肿胀和骨暴露。做了活检,用MRONJ确认EBVMCU的诊断。由于骨骼暴露的扩大，在全身麻醉下进行下颌骨边缘切除术，以治疗残留的MRONJ。在为期两年的随访中，未观察到复发的证据.
