PDF(Pubmed)
Abstract：
Endocrine disorders pose significant challenges in the management of critically ill patients, contributing to morbidity and mortality in intensive care settings. Timely detection of these disorders is essential to optimizing patient outcomes. Biomarkers, as measurable indicators of biological processes or disease states, play a crucial role in the early identification and monitoring of endocrine dysfunction. This comprehensive review examines the role of biomarkers in the early detection of endocrine disorders in critical illnesses. We provide an overview of common endocrine disorders encountered in the intensive care unit (ICU) and discuss the impact of endocrine dysregulation on patient outcomes. Additionally, we classify biomarkers and explore their significance in diagnosing and monitoring endocrine disorders, including thyroid dysfunction, adrenal insufficiency, and hypopituitarism. Furthermore, we discuss the clinical applications of biomarkers, including their utility in guiding therapeutic interventions, monitoring disease progression, and predicting outcomes in critical illnesses. Emerging trends and future directions in biomarker research are also highlighted, emphasizing the need for continued investigation into novel biomarkers and technological advancements. Finally, we underscore the potential of biomarkers to revolutionize the early detection and management of endocrine disorders in critical illnesses, ultimately improving patient care and outcomes in the ICU.
摘要：
内分泌紊乱对危重病人的管理构成重大挑战，导致重症监护环境中的发病率和死亡率。及时发现这些疾病对于优化患者预后至关重要。生物标志物,作为生物过程或疾病状态的可测量指标，在内分泌功能障碍的早期识别和监测中起着至关重要的作用。这篇全面的综述探讨了生物标志物在重症疾病内分泌紊乱早期检测中的作用。我们概述了重症监护病房（ICU）中常见的内分泌疾病，并讨论了内分泌失调对患者预后的影响。此外,我们对生物标志物进行分类，并探讨其在诊断和监测内分泌紊乱中的意义，包括甲状腺功能障碍,肾上腺功能不全,和垂体功能低下。此外，我们讨论了生物标志物的临床应用，包括它们在指导治疗干预方面的效用，监测疾病进展，并预测重大疾病的结果。还强调了生物标志物研究的新兴趋势和未来方向，强调需要继续研究新的生物标志物和技术进步。最后,我们强调了生物标志物在重大疾病内分泌紊乱的早期发现和管理方面的潜力，最终改善ICU患者的护理和预后。
