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Abstract：
Background Hypertension significantly contributes to the severity, prolonged hospitalization, the need for intensive care, and mortality of COVID-19 patients. However, the data is still evolving. This study investigated the predictors of severity among hypertensive COVID-19 patients. Methodology This cohort study included 333 hospitalized hypertensive COVID-19 patients at the Indus Hospital, Karachi, Pakistan, from April 2021 to October 2021. The study evaluated the clinical features, antihypertensive therapy, and predictors of severity. A multivariable binary logistic regression model was used to determine severity predictors using IBM SPSS Statistics for Windows, Version 27.0 (Released 2020; IBM Corp., Armonk, NY, USA). Results The majority of hypertensive COVID-19 patients were females (54.7%), aged <65 years (55.8%), and coexisted with diabetes mellitus (56.5%). The independent predictors of severity were male (aOR 2.65, 95% CI, 1.08-6.51; p < 0.033), fever (aOR 3.52, 95% CI, 1.24-9.92; p = 0.017), shortness of breath (aOR 4.49, 95% CI, 1.73-11.63; p = 0.002), oxygen saturation (<90%) (aOR 87.39, 95% CI, 19.15-398.75; p < 0.001), and D-dimer (>0.5 mcg/ml) (aOR 3.03, 95% CI, 1.19-7.71; p = 0.020). Conclusions Our study concluded that males with fever before admission, shortness of breath, lower oxygen saturation, and elevated D-dimer are the predictors of severity among hypertensive COVID-19 patients.
摘要：
背景高血压对严重程度有显著贡献，住院时间延长,需要重症监护,和COVID-19患者的死亡率。然而,数据仍在不断发展。这项研究调查了高血压COVID-19患者严重程度的预测因素。方法学这项队列研究包括在印度河医院住院的333例高血压COVID-19患者，卡拉奇,巴基斯坦,从2021年4月到2021年10月。该研究评估了临床特征，抗高血压治疗,和严重程度的预测因子。使用IBMSPSSStatisticsforWindows，使用多变量二元逻辑回归模型来确定严重程度预测因子。27.0版（2020年发布；IBMCorp.,Armonk,NY,美国）。结果COVID-19高血压患者以女性居多(54.7%),年龄<65岁（55.8%），并与糖尿病并存(56.5%)。严重程度的独立预测因子为男性(aOR2.65,95%CI,1.08-6.51;p<0.033),发烧（aOR3.52，95%CI，1.24-9.92；p=0.017），呼吸短促（aOR4.49，95%CI，1.73-11.63；p=0.002），氧饱和度（<90％）（aOR87.39，95％CI，19.15-398.75；p<0.001），D-二聚体(>0.5mcg/ml)(aOR3.03,95%CI,1.19-7.71;p=0.020)。结论我们的研究得出结论，男性入院前发烧，呼吸急促,较低的氧饱和度,D-二聚体升高是COVID-19高血压患者严重程度的预测因子。
