PDF(Pubmed)
Abstract：
UNASSIGNED: Spontaneous Intracerebral hemorrhage (ICH) in young patients is less common and not well studied compared to ICH in older patients. The etiology, risk factors and outcome of ICH in young patients may have regional and ethnic differences. The study aims to investigate the clinical characteristics, risk factors, etiology and outcome of spontaneous intracerebral hemorrhage in young adults in Somalia.
UNASSIGNED: The study enrolled 168 young patients with ICH (16-50 years) admitted to the neurology department of a tertiary hospital from 2019 to 2022. The information about the demographic details, documented ICH risk factors, etiology and patients\' clinical status were retrieved. The etiology of ICH was determined based on clinical, laboratory and radiological findings. Intra-hospital survival status and associated factors were assessed.
UNASSIGNED: The mean age of the patients was 35±8.6 years. 99 (59%) of patients were male while 69 (41%) were females. Hypertension 48 (29%) was the most common risk factor, followed by substance abuse. Hypertensive hemorrhage was the most common etiology of ICH 60 (35.7%), followed by cerebral venous thrombosis (CVT) 5(15%), substance abuse 23 (13.7%) and arteriovenous malformation (AVM) in 10 (6%). AVM, CVT, cavernoma, eclampsia, substance abuse and cryptogenic etiology were more common in the 2nd and 3rd decades whereas hypertension was more common in the 4th and 5th decade. Intrahospital mortality was 28% in this study. Factors predicting intrahospital mortality were hematoma volume of greater than 30mL, thrombolytic etiology, brainstem ICH location, substance abuse related etiology, presence of associated mass effect, low GCS score on admission, high systolic blood pressure on admission, and the presence of chronic renal failure.
UNASSIGNED: In this study, hypertension, substance abuse, CVT and vascular malformation are the leading causes of ICH in young adults. Intracerebral hemorrhage in the young has different spectrum of etiologies and factors associated with short-term mortality compared to older patients.
UNASSIGNED: The study enrolled 168 young patients with ICH (16-50 years) admitted to the neurology department of a tertiary hospital from 2019 to 2022. The information about the demographic details, documented ICH risk factors, etiology and patients\' clinical status were retrieved. The etiology of ICH was determined based on clinical, laboratory and radiological findings. Intra-hospital survival status and associated factors were assessed.
UNASSIGNED: The mean age of the patients was 35±8.6 years. 99 (59%) of patients were male while 69 (41%) were females. Hypertension 48 (29%) was the most common risk factor, followed by substance abuse. Hypertensive hemorrhage was the most common etiology of ICH 60 (35.7%), followed by cerebral venous thrombosis (CVT) 5(15%), substance abuse 23 (13.7%) and arteriovenous malformation (AVM) in 10 (6%). AVM, CVT, cavernoma, eclampsia, substance abuse and cryptogenic etiology were more common in the 2nd and 3rd decades whereas hypertension was more common in the 4th and 5th decade. Intrahospital mortality was 28% in this study. Factors predicting intrahospital mortality were hematoma volume of greater than 30mL, thrombolytic etiology, brainstem ICH location, substance abuse related etiology, presence of associated mass effect, low GCS score on admission, high systolic blood pressure on admission, and the presence of chronic renal failure.
UNASSIGNED: In this study, hypertension, substance abuse, CVT and vascular malformation are the leading causes of ICH in young adults. Intracerebral hemorrhage in the young has different spectrum of etiologies and factors associated with short-term mortality compared to older patients.
摘要：
■与老年患者的ICH相比，年轻患者的自发性脑出血（ICH）较不常见，也没有得到很好的研究。病因,年轻患者ICH的危险因素和结局可能存在地区和种族差异.本研究旨在探讨其临床特点,危险因素，索马里年轻人自发性脑出血的病因和结局。
■该研究纳入了从2019年至2022年入住三级医院神经内科的168名年轻ICH患者（16-50岁）。关于人口统计细节的信息，记录ICH风险因素，检索病因和患者临床状况。根据临床确定ICH的病因，实验室和放射学发现。评估院内生存状况和相关因素。
■患者的平均年龄为35±8.6岁。99例（59％）患者为男性，69例（41％）为女性。高血压48（29%）是最常见的危险因素，其次是药物滥用。高血压性出血是ICH60的最常见病因(35.7%),其次是脑静脉血栓形成（CVT）5（15%），药物滥用23（13.7%）和动静脉畸形（AVM）10（6%）。AVM,CVT,海绵体瘤,子痫,药物滥用和隐源性病因在第2和第3个十年更为常见,而高血压在第4和第5个十年更为常见.在这项研究中，院内死亡率为28%。预测院内死亡率的因素是血肿体积大于30mL，溶栓病因，脑干ICH位置,药物滥用相关的病因，存在相关的质量效应，入学时GCS分数低，入院时收缩压高,和慢性肾衰竭的存在。
■在这项研究中，高血压,药物滥用,CVT和血管畸形是年轻人ICH的主要原因。与老年患者相比，年轻人的脑出血具有不同的病因和与短期死亡率相关的因素。
■该研究纳入了从2019年至2022年入住三级医院神经内科的168名年轻ICH患者（16-50岁）。关于人口统计细节的信息，记录ICH风险因素，检索病因和患者临床状况。根据临床确定ICH的病因，实验室和放射学发现。评估院内生存状况和相关因素。
■患者的平均年龄为35±8.6岁。99例（59％）患者为男性，69例（41％）为女性。高血压48（29%）是最常见的危险因素，其次是药物滥用。高血压性出血是ICH60的最常见病因(35.7%),其次是脑静脉血栓形成（CVT）5（15%），药物滥用23（13.7%）和动静脉畸形（AVM）10（6%）。AVM,CVT,海绵体瘤,子痫,药物滥用和隐源性病因在第2和第3个十年更为常见,而高血压在第4和第5个十年更为常见.在这项研究中，院内死亡率为28%。预测院内死亡率的因素是血肿体积大于30mL，溶栓病因，脑干ICH位置,药物滥用相关的病因，存在相关的质量效应，入学时GCS分数低，入院时收缩压高,和慢性肾衰竭的存在。
■在这项研究中，高血压,药物滥用,CVT和血管畸形是年轻人ICH的主要原因。与老年患者相比，年轻人的脑出血具有不同的病因和与短期死亡率相关的因素。
