PDF(Pubmed)
Abstract：
Aging is closely associated with inflammation, which affects renal function reserve (RFR) in the kidneys. This study aims to investigate the impact of reduced RFR reduction on kidney aging and the influence of renal inflammation and RFR reduction on this process. Natural aging rats and those subjected to unilateral nephrectomy (UNX), 1/6 nephrectomy (1/6NX), and unilateral ureteral obstruction (UUO) were observed at 6, 12, 18, and 21 months. Our findings suggest that RFR reduction and renal inflammation can accelerate kidney aging, and inflammation contributes more. Metabolomics analysis revealed alterations in amino acid metabolism contribute to RFR decline. Furthermore, experiments in vitro confirmed the involvement of pentose phosphate pathway (PPP) in promoting aging though inflammation. Our research provides novel insights into for the mechanism of kidney aging and provides indirect support for clinical treatment decisions, such as addressing kidney inflammation, stones, or tumors that may necessitate partial or complete nephrectomy.
摘要：
衰老与炎症密切相关，影响肾脏的肾功能储备（RFR）。本研究旨在探讨降低的RFR降低对肾脏衰老的影响以及肾脏炎症和RFR降低对这一过程的影响。自然衰老大鼠和接受单侧肾切除术（UNX）的大鼠，1/6肾切除术（1/6NX），在6、12、18和21个月时观察到单侧输尿管梗阻（UUO）。我们的研究结果表明，RFR降低和肾脏炎症可以加速肾脏衰老，炎症贡献更大。代谢组学分析显示氨基酸代谢的改变有助于RFR下降。此外，体外实验证实了戊糖磷酸途径（PPP）通过炎症促进衰老。我们的研究为肾脏衰老的机制提供了新的见解，并为临床治疗决策提供了间接支持。比如解决肾脏炎症，石头,或可能需要部分或完全肾切除术的肿瘤。
