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Abstract：
UNASSIGNED: To deepen the imaging-pathological mechanism of primary central nervous system lymphoma (PCNSL) and provide a theoretical basis for clinical diagnosis and treatment, the functional magnetic resonance imaging (fMRI) characteristics of PCNSL were analyzed, and the relationship between the fMRI characteristics and vasculogenic mimicry (VM) and reticular fiber in PCNSL was discussed.
UNASSIGNED: Ninety-six patients with PCNSL treated in our hospital were divided into three groups according to the pathological examination results, including strong positive group of VM (n = 40), weak positive group of VM (n = 56), strong positive group of reticular fiber (n = 45) and weak positive group of reticular fiber (n = 51). The levels of augmentation index and apparent diffusion coefficient (ADC) were compared among the groups. receiver operator characteristic (ROC) curve analysis was used to analyze the clinical value of ADC value in differential diagnosis of PCNSL.
UNASSIGNED: The levels of augmentation index in the strong positive group of VM were significantly higher than that in the weak positive group of VM, and the ADC value in the strong positive group of VM was significantly lower than that in the weak positive group of VM (P < 0.001). The levels of augmentation index in the strong positive group of reticular fiber were significantly higher than that in the weak positive group of reticular fiber, and ADC value in the strong positive group of reticular fiber was significantly lower than that in reticular fiber weak positive group (P < 0.001). Pearson correlation analysis showed that the levels of augmentation index were positively correlated with VM and reticular fiber (r = 0.529, 0.548, P < 0.001) and the ADC value was negatively correlated with VM and reticular fiber (r = -0.485, -0.513, P < 0.001). There was a significant negative correlation between necrotic lesions and VM (r = -0.185, P < 0.05). The area under the curve (AUC) values of average ADC value, minimum ADC value, and maximum ADC value for individual differential diagnosis of PCNSL were 0.920, 0.901, and 0.702, while the AUC of the combined differential diagnosis was 0.985, with a sensitivity of 95.00 % and a specificity of 92.70 %.
UNASSIGNED: The levels of augmentation index and the ADC value of PCNSL focus are significantly correlated with VM and reticular fiber, and there is a strong negative correlation between necrotic lesions and VM. MRI imaging technology is of great significance in revealing the biological behavior of PCNSL, which can effectively reveal the relationship between VM and reticular fibers and the MRI characteristics in PCNSL, thereby providing a new imaging basis for the clinical diagnosis and treatment of PCNSL.
UNASSIGNED: Ninety-six patients with PCNSL treated in our hospital were divided into three groups according to the pathological examination results, including strong positive group of VM (n = 40), weak positive group of VM (n = 56), strong positive group of reticular fiber (n = 45) and weak positive group of reticular fiber (n = 51). The levels of augmentation index and apparent diffusion coefficient (ADC) were compared among the groups. receiver operator characteristic (ROC) curve analysis was used to analyze the clinical value of ADC value in differential diagnosis of PCNSL.
UNASSIGNED: The levels of augmentation index in the strong positive group of VM were significantly higher than that in the weak positive group of VM, and the ADC value in the strong positive group of VM was significantly lower than that in the weak positive group of VM (P < 0.001). The levels of augmentation index in the strong positive group of reticular fiber were significantly higher than that in the weak positive group of reticular fiber, and ADC value in the strong positive group of reticular fiber was significantly lower than that in reticular fiber weak positive group (P < 0.001). Pearson correlation analysis showed that the levels of augmentation index were positively correlated with VM and reticular fiber (r = 0.529, 0.548, P < 0.001) and the ADC value was negatively correlated with VM and reticular fiber (r = -0.485, -0.513, P < 0.001). There was a significant negative correlation between necrotic lesions and VM (r = -0.185, P < 0.05). The area under the curve (AUC) values of average ADC value, minimum ADC value, and maximum ADC value for individual differential diagnosis of PCNSL were 0.920, 0.901, and 0.702, while the AUC of the combined differential diagnosis was 0.985, with a sensitivity of 95.00 % and a specificity of 92.70 %.
UNASSIGNED: The levels of augmentation index and the ADC value of PCNSL focus are significantly correlated with VM and reticular fiber, and there is a strong negative correlation between necrotic lesions and VM. MRI imaging technology is of great significance in revealing the biological behavior of PCNSL, which can effectively reveal the relationship between VM and reticular fibers and the MRI characteristics in PCNSL, thereby providing a new imaging basis for the clinical diagnosis and treatment of PCNSL.
摘要：
■深化原发性中枢神经系统淋巴瘤（PCNSL）的影像学病理机制，为临床诊断和治疗提供理论依据。分析PCNSL的功能磁共振成像(fMRI)特征,讨论了PCNSL的fMRI特征与血管生成拟态（VM）和网状纤维之间的关系。
■我院收治的96例PCNSL患者根据病理检查结果分为3组，包括强阳性VM组(n=40)，VM弱阳性组(n=56)，网状纤维强阳性组(n=45)和网状纤维弱阳性组(n=51)。比较各组之间的增强指数和表观扩散系数（ADC）水平。采用受试者操作特征(ROC)曲线分析,分析ADC值在PCNSL鉴别诊断中的临床价值。
■VM强阳性组的增强指数水平明显高于VM弱阳性组，VM强阳性组ADC值显著低于VM弱阳性组(P<0.001)。网状纤维强阳性组的增强指数水平明显高于网状纤维弱阳性组，网状纤维强阳性组ADC值显著低于网状纤维弱阳性组(P<0.001)。Pearson相关分析显示，增强指数水平与VM和网状纤维呈正相关（r=0.529、0.548，P<0.001），ADC值与VM和网状纤维呈负相关（r=-0.485、-0.513，P<0.001）。坏死性病变与VM呈显著负相关(r=-0.185,P<0.05)。平均ADC值的曲线下面积(AUC)值,最小ADC值,PCNSL个体鉴别诊断的最大ADC值分别为0.920、0.901和0.702，联合鉴别诊断的AUC为0.985，敏感性为95.00%，特异性为92.70%。
■PCNSL病灶的增强指数和ADC值与VM和网状纤维显著相关，坏死性病变与VM之间存在很强的负相关。MRI成像技术对揭示PCNSL的生物学行为具有重要意义,能有效揭示VM与网状纤维的关系及PCNSL的MRI特征,从而为PCNSL的临床诊断和治疗提供新的影像学依据。
■我院收治的96例PCNSL患者根据病理检查结果分为3组，包括强阳性VM组(n=40)，VM弱阳性组(n=56)，网状纤维强阳性组(n=45)和网状纤维弱阳性组(n=51)。比较各组之间的增强指数和表观扩散系数（ADC）水平。采用受试者操作特征(ROC)曲线分析,分析ADC值在PCNSL鉴别诊断中的临床价值。
■VM强阳性组的增强指数水平明显高于VM弱阳性组，VM强阳性组ADC值显著低于VM弱阳性组(P<0.001)。网状纤维强阳性组的增强指数水平明显高于网状纤维弱阳性组，网状纤维强阳性组ADC值显著低于网状纤维弱阳性组(P<0.001)。Pearson相关分析显示，增强指数水平与VM和网状纤维呈正相关（r=0.529、0.548，P<0.001），ADC值与VM和网状纤维呈负相关（r=-0.485、-0.513，P<0.001）。坏死性病变与VM呈显著负相关(r=-0.185,P<0.05)。平均ADC值的曲线下面积(AUC)值,最小ADC值,PCNSL个体鉴别诊断的最大ADC值分别为0.920、0.901和0.702，联合鉴别诊断的AUC为0.985，敏感性为95.00%，特异性为92.70%。
■PCNSL病灶的增强指数和ADC值与VM和网状纤维显著相关，坏死性病变与VM之间存在很强的负相关。MRI成像技术对揭示PCNSL的生物学行为具有重要意义,能有效揭示VM与网状纤维的关系及PCNSL的MRI特征,从而为PCNSL的临床诊断和治疗提供新的影像学依据。
