PDF(Pubmed)
Abstract：
Hydroxyapatite (HAp) coatings currently have limited therapeutic applications because they lack anti-infection, osteoinductivity, and poor mechanical characteristics. On the titanium substrate, electrochemical deposition (ECD) was used to construct the strontium (Sr)-featuring hydroxyapatite (HAp)/graphene oxides (GO)/linezolid (LZ) nanomaterial coated with antibacterial and drug delivery properties. The newly fabricated nanomaterials were confirmed by X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) analysis and morphological features were examined by scanning electron microscope (SEM) analysis. The results reveal multiple nucleation sites for SrHAp/GO/LZ composite coatings due to oxygen-comprising moieties on the 2D surface of GO. It was shown to be favorable for osteoblast proliferation and differentiation. The elastic modulus and hardness of LZ nanocomposite with SrHAp/GO/LZ coatings were increased by 67 % and 121 %, respectively. An initial 5 h burst of LZ release from the SrHAp/GO/LZ coating was followed by 14 h of gradual release, owing to LZ\'s physical and chemical adsorption. The SrHAp/GO/LZ coating effectively inhibited both S. epidermidis and S. aureus, and the inhibition lasted for three days, as demonstrated by the inhibition zone and colony count assays. When MG-63 cells are coated with SrHAp/GO/LZ composite coating, their adhesion, proliferation, and differentiation greatly improve when coated with pure titanium. A novel surface engineering nanomaterial for treating and preventing osteoporotic bone defects, SrHAp/GO/LZ, was shown to have high mechanical characteristics, superior antibacterial abilities, and osteoinductivity.
摘要：
羟基磷灰石（HAp）涂层目前具有有限的治疗应用，因为它们缺乏抗感染，骨诱导性，和差的机械特性。在钛基板上，电化学沉积（ECD）用于构建具有抗菌和药物递送性能的锶（Sr）特征羟基磷灰石（HAp）/氧化石墨烯（GO）/利奈唑胺（LZ）纳米材料。通过X射线衍射分析（XRD）证实了新制备的纳米材料，傅里叶变换红外光谱(FTIR),和X射线光电子能谱（XPS）分析和形态学特征的扫描电子显微镜（SEM）分析。结果显示由于GO的2D表面上的含氧部分,SrHAp/GO/LZ复合涂层的多个成核位点。它被证明有利于成骨细胞的增殖和分化。具有SrHAp/GO/LZ涂层的LZ纳米复合材料的弹性模量和硬度分别提高了67％和121％，分别。从SrHAp/GO/LZ涂层释放LZ最初5小时，然后逐渐释放14小时，由于LZ的物理和化学吸附。SrHAp/GO/LZ涂层能有效抑制表皮葡萄球菌和金黄色葡萄球菌,抑制持续了三天，如抑制区和菌落计数测定所证明的。当MG-63电池涂有SrHAp/GO/LZ复合涂层时，他们的附着力，扩散,和分化大大提高，当涂覆纯钛。一种用于治疗和预防骨质疏松性骨缺损的新型表面工程纳米材料，SrHAp/GO/LZ,被证明具有很高的机械特性，优越的抗菌能力，和骨诱导性。
