PDF(Pubmed)
Abstract：
An association between periodontal disease and oral squamous cell carcinoma (OSCC) has been recognized. However, there is no causal relationship between the two. The polymicrobial etiology of periodontal disease is confirmed, and so are the proven etiological factors for OSCC. Inflammation lies at the core of periodontal pathogenesis induced by the putative microbes. OSCC has inflammatory overtures in its pathobiology. Bacterial species involved in periodontal disease have been extensively documented and validated. The microbial profile in OSCC has been explored with no specific conclusions. The scientific reasoning to link a common microbial signature that connects periodontal disease to OSCC has led to many studies but has not provided conclusive evidence. Therefore, it would be beneficial to know the status of any plausible microbiota having a similarity in periodontal disease and OSCC. This brief review attempted to clarify the existence of a dysbiotic \"fingerprint\" that may link these two diseases. The review examined the literature with a focused objective of identifying periodontal microbial profiles in OSCC that could provide insights into pathogen commonality. The review concluded that there is great diversity in microbial association, but important bacterial species that correlate with periodontal disease and OSCC are forthcoming.
摘要：
牙周疾病与口腔鳞状细胞癌（OSCC）之间的关联已得到认可。然而,两者之间没有因果关系。牙周疾病的多微生物病因得到证实，OSCC的已证实的病因也是如此。炎症是由假定的微生物引起的牙周发病机制的核心。OSCC在其病理生物学中具有炎症表现。与牙周病有关的细菌种类已被广泛记录和验证。OSCC中的微生物谱已经被探索，没有具体的结论。将牙周疾病与OSCC联系起来的常见微生物特征的科学推理导致了许多研究，但没有提供确凿的证据。因此,了解在牙周病和OSCC中具有相似性的任何合理微生物群的状态将是有益的。这篇简短的评论试图阐明可能将这两种疾病联系起来的生态失调“指纹”的存在。该综述审查了文献，重点是鉴定OSCC中的牙周微生物谱，这可以提供对病原体共性的见解。该综述的结论是，微生物协会存在很大的多样性，但与牙周病和OSCC相关的重要细菌物种即将到来。
