PDF(Pubmed)
Abstract：
UNASSIGNED: Fluid loading improves hemodynamic stability and reduces the incidence rate of post-spinal anesthesia hypotension when prophylactic vasopressors are administered. We investigated the impact of different crystalloid coload volumes on the 90% effective dose (ED) of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension in non-hypertensive patients undergoing cesarean section.
UNASSIGNED: Patients were randomly allocated to receive one of the different crystalloid coload volumes (0mL/kg [0mL/kg Group], 5mL kg [5mL/kg Group], and 10mL kg [10mL/kg Group]) in combination with prophylactic norepinephrine infusion immediately after the induction of spinal anesthesia. The prophylactic norepinephrine infusion doses were determined using the up-and-down sequential allocation methodology, with an initial dose of 0.025 μg/kg/min and a gradient of 0.005 μg/kg/min. The primary endpoint was the effective dose at which 90% (ED 90) of patients responded to prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension.
UNASSIGNED: The estimated effective dose of norepinephrine infusion, at which 90% (ED 90) of patients responded, was found to be 0.084 (95% CI, 0.070 to 0.86), 0.074 (95% CI, 0.059 to 0.077), and 0.063 (95% CI, 0.053 to 0.064) μg/kg/min in the three groups, respectively.
UNASSIGNED: A crystalloid coload of 5 mL/kg or 10 mL/kg, as opposed to the groups receiving 0 mL/kg crystalloid coloads, resulted in a reduction of approximately 11.9% and 25.0%, respectively, in the ED90 of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension during cesarean section.
UNASSIGNED: Patients were randomly allocated to receive one of the different crystalloid coload volumes (0mL/kg [0mL/kg Group], 5mL kg [5mL/kg Group], and 10mL kg [10mL/kg Group]) in combination with prophylactic norepinephrine infusion immediately after the induction of spinal anesthesia. The prophylactic norepinephrine infusion doses were determined using the up-and-down sequential allocation methodology, with an initial dose of 0.025 μg/kg/min and a gradient of 0.005 μg/kg/min. The primary endpoint was the effective dose at which 90% (ED 90) of patients responded to prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension.
UNASSIGNED: The estimated effective dose of norepinephrine infusion, at which 90% (ED 90) of patients responded, was found to be 0.084 (95% CI, 0.070 to 0.86), 0.074 (95% CI, 0.059 to 0.077), and 0.063 (95% CI, 0.053 to 0.064) μg/kg/min in the three groups, respectively.
UNASSIGNED: A crystalloid coload of 5 mL/kg or 10 mL/kg, as opposed to the groups receiving 0 mL/kg crystalloid coloads, resulted in a reduction of approximately 11.9% and 25.0%, respectively, in the ED90 of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension during cesarean section.
摘要：
■当施用预防性血管加压剂时，流体负荷改善了血液动力学稳定性并降低了脊髓麻醉后低血压的发生率。我们研究了不同的晶体结肠体积对预防性去甲肾上腺素输注90％有效剂量（ED）的影响，以预防非高血压剖宫产患者的脊髓麻醉后低血压。
■患者被随机分配接受一种不同的晶体结肠体积（0mL/kg[0mL/kg组]，5mLkg[5mL/kg组]，和10mLkg[10mL/kg组]）在脊髓麻醉诱导后立即与预防性去甲肾上腺素输注联合。使用上下顺序分配方法确定预防性去甲肾上腺素输注剂量，初始剂量为0.025μg/kg/min，梯度为0.005μg/kg/min。主要终点是90%（ED90）的患者对预防性去甲肾上腺素输注有反应以预防脊髓麻醉后低血压的有效剂量。
■去甲肾上腺素输注的估计有效剂量，90%(ED90)的患者有反应，被发现为0.084(95%CI，0.070至0.86)，0.074（95%CI，0.059至0.077），和0.063（95％CI，0.053至0.064）μg/kg/min，分别。
■5mL/kg或10mL/kg的晶体混合物，与接受0mL/kg晶体类coloads的组相反，减少了约11.9%和25.0%，分别,在剖宫产术中预防性输注去甲肾上腺素预防脊髓麻醉后低血压的ED90中。
■患者被随机分配接受一种不同的晶体结肠体积（0mL/kg[0mL/kg组]，5mLkg[5mL/kg组]，和10mLkg[10mL/kg组]）在脊髓麻醉诱导后立即与预防性去甲肾上腺素输注联合。使用上下顺序分配方法确定预防性去甲肾上腺素输注剂量，初始剂量为0.025μg/kg/min，梯度为0.005μg/kg/min。主要终点是90%（ED90）的患者对预防性去甲肾上腺素输注有反应以预防脊髓麻醉后低血压的有效剂量。
■去甲肾上腺素输注的估计有效剂量，90%(ED90)的患者有反应，被发现为0.084(95%CI，0.070至0.86)，0.074（95%CI，0.059至0.077），和0.063（95％CI，0.053至0.064）μg/kg/min，分别。
■5mL/kg或10mL/kg的晶体混合物，与接受0mL/kg晶体类coloads的组相反，减少了约11.9%和25.0%，分别,在剖宫产术中预防性输注去甲肾上腺素预防脊髓麻醉后低血压的ED90中。
