PDF(Pubmed)
Abstract：
UNASSIGNED: Research examining the bidirectional relationship between C-reactive protein (CRP) and depressive symptoms, while accounting for cumulative effect of repeated episodes of CRP or depressive symptoms, is currently deficient in non-Western populations.
UNASSIGNED: A nationally representative population-based cohort data from the Chinese Health and Retirement Longitudinal Study (CHARLS) was utilized. In bi-directional analysis, we considered both single determinations and two successive determinations of CRP or depressive symptoms. Multivariate logistic regression assessed the association between elevated CRP levels at baseline or repeated episodes of CRP elevations over two successive determinations and subsequent elevated depressive symptoms, and vice versa.
UNASSIGNED: Although single determinations of CRP or depressive symptoms yielded non-significant results in both directions, full multivariate models, adjusting for baseline depressive symptoms, socio-demographic characteristics, health-related behaviors, metabolic measures, and health status, revealed a significantly positive association based on two successive determinations of CRP or depressive symptoms. This significant association was observed between cumulative effects of sustained CRP elevations over two successive determinations (2 vs. 0) and subsequent elevated depressive symptoms (OR=1.58; 95% CI: 1.15 to 2.17) and between cumulative effect of repeated episodes of depression (2 vs. 0) and later elevated CRP (OR=1.26; 95% CI: 1.02 to 1.56). Furthermore, sex-stratified analyses confirmed the robustness of these relationships.
UNASSIGNED: There are bidirectional associations between depressive symptoms and CRP, driven by the cumulative effect of repeated episodes of CRP or depressive symptoms among middle-aged and older Chinese adults. These findings hold significant clinical implications, highlighting the potential of both anti-inflammatory and anti-depression approaches.
UNASSIGNED: A nationally representative population-based cohort data from the Chinese Health and Retirement Longitudinal Study (CHARLS) was utilized. In bi-directional analysis, we considered both single determinations and two successive determinations of CRP or depressive symptoms. Multivariate logistic regression assessed the association between elevated CRP levels at baseline or repeated episodes of CRP elevations over two successive determinations and subsequent elevated depressive symptoms, and vice versa.
UNASSIGNED: Although single determinations of CRP or depressive symptoms yielded non-significant results in both directions, full multivariate models, adjusting for baseline depressive symptoms, socio-demographic characteristics, health-related behaviors, metabolic measures, and health status, revealed a significantly positive association based on two successive determinations of CRP or depressive symptoms. This significant association was observed between cumulative effects of sustained CRP elevations over two successive determinations (2 vs. 0) and subsequent elevated depressive symptoms (OR=1.58; 95% CI: 1.15 to 2.17) and between cumulative effect of repeated episodes of depression (2 vs. 0) and later elevated CRP (OR=1.26; 95% CI: 1.02 to 1.56). Furthermore, sex-stratified analyses confirmed the robustness of these relationships.
UNASSIGNED: There are bidirectional associations between depressive symptoms and CRP, driven by the cumulative effect of repeated episodes of CRP or depressive symptoms among middle-aged and older Chinese adults. These findings hold significant clinical implications, highlighting the potential of both anti-inflammatory and anti-depression approaches.
摘要：
■研究C反应蛋白（CRP）与抑郁症状之间的双向关系，考虑到CRP或抑郁症状反复发作的累积效应，目前缺乏非西方人口。
■使用了来自中国健康与退休纵向研究（CHARLS）的全国代表性人群队列数据。在双向分析中，我们考虑了CRP或抑郁症状的单次测定和两次连续测定.多变量逻辑回归评估了基线时CRP水平升高或连续两次测定中CRP升高的重复发作与随后的抑郁症状升高之间的关联。反之亦然。
■尽管CRP或抑郁症状的单一测定在两个方向上都没有显著结果，完整的多变量模型，调整基线抑郁症状，社会人口特征，与健康相关的行为，代谢措施，和健康状况，根据CRP或抑郁症状的两次连续测定，显示出显着的正相关。在连续两次测定的持续CRP升高的累积效应之间观察到了这种显着关联（2vs.0）和随后的抑郁症状升高（OR=1.58；95％CI：1.15至2.17）以及反复发作抑郁症的累积效应之间（2vs.0）和后期CRP升高（OR=1.26；95%CI：1.02至1.56）。此外，性别分层分析证实了这些关系的稳健性。
■抑郁症状和CRP之间存在双向关联，由中国中老年人CRP反复发作或抑郁症状的累积效应驱动。这些发现具有重要的临床意义，强调抗炎和抗抑郁方法的潜力。
■使用了来自中国健康与退休纵向研究（CHARLS）的全国代表性人群队列数据。在双向分析中，我们考虑了CRP或抑郁症状的单次测定和两次连续测定.多变量逻辑回归评估了基线时CRP水平升高或连续两次测定中CRP升高的重复发作与随后的抑郁症状升高之间的关联。反之亦然。
■尽管CRP或抑郁症状的单一测定在两个方向上都没有显著结果，完整的多变量模型，调整基线抑郁症状，社会人口特征，与健康相关的行为，代谢措施，和健康状况，根据CRP或抑郁症状的两次连续测定，显示出显着的正相关。在连续两次测定的持续CRP升高的累积效应之间观察到了这种显着关联（2vs.0）和随后的抑郁症状升高（OR=1.58；95％CI：1.15至2.17）以及反复发作抑郁症的累积效应之间（2vs.0）和后期CRP升高（OR=1.26；95%CI：1.02至1.56）。此外，性别分层分析证实了这些关系的稳健性。
■抑郁症状和CRP之间存在双向关联，由中国中老年人CRP反复发作或抑郁症状的累积效应驱动。这些发现具有重要的临床意义，强调抗炎和抗抑郁方法的潜力。
