PDF(Pubmed)
Abstract：
UNASSIGNED: This review aims to elucidate the etiologies of brain abscesses in the tropics. Despite the similarities in causes of brain abscesses across global regions, tropical settings manifest distinguishing characteristics, prominently observed on computed tomography or magnetic resonance imaging.
UNASSIGNED: In tropical climates, the leading conditions predisposing individuals to brain abscesses are polymicrobial bacterial infections originating from paranasal sinuses, dental sources, and otitis media. However, the tropics present unique etiologies to be aware of, including Trypanosoma cruzi (Chagas disease), free-living amoebas like Balamuthia mandrillaris, infections from Burkholderia pseudomallei (melioidosis), fungi such as Talaromyces marneffei, and Mycobacterium tuberculosis. Given the differential diagnoses, which include neoplastic, inflammatory, and demyelinating diseases, a stereotactic biopsy coupled with a microbiological assessment remains valuable for accurate diagnosis.
UNASSIGNED: In tropical regions, brain abscesses are a concern when confronted with mass-occupying or other types of brain lesions. Successful clinical management of brain abscesses typically combines surgical intervention and extended anti-microbial treatment. However, specific parasitic invasions like Chagas disease, free-living amoebas, and Entamoeba histolytica necessitate targeted anti-parasitic therapies. Furthermore, international policy efforts should focus on prevention measures in resource limited regions with heightened risks and disease burden.
UNASSIGNED: In tropical climates, the leading conditions predisposing individuals to brain abscesses are polymicrobial bacterial infections originating from paranasal sinuses, dental sources, and otitis media. However, the tropics present unique etiologies to be aware of, including Trypanosoma cruzi (Chagas disease), free-living amoebas like Balamuthia mandrillaris, infections from Burkholderia pseudomallei (melioidosis), fungi such as Talaromyces marneffei, and Mycobacterium tuberculosis. Given the differential diagnoses, which include neoplastic, inflammatory, and demyelinating diseases, a stereotactic biopsy coupled with a microbiological assessment remains valuable for accurate diagnosis.
UNASSIGNED: In tropical regions, brain abscesses are a concern when confronted with mass-occupying or other types of brain lesions. Successful clinical management of brain abscesses typically combines surgical intervention and extended anti-microbial treatment. However, specific parasitic invasions like Chagas disease, free-living amoebas, and Entamoeba histolytica necessitate targeted anti-parasitic therapies. Furthermore, international policy efforts should focus on prevention measures in resource limited regions with heightened risks and disease burden.
摘要：
■这篇综述旨在阐明热带地区脑脓肿的病因。尽管全球各地区脑脓肿的病因相似，热带环境表现出显著的特征，在计算机断层扫描或磁共振成像上显著观察到。
■在热带气候中，易患脑脓肿的主要条件是源自鼻旁窦的多微生物细菌感染，牙科来源，和中耳炎.然而,热带地区呈现出独特的病因，包括克氏锥虫（锥虫病），像Balamuthiamandrillaris一样自由生活的变形虫，假性伯克霍尔德菌感染（类骨病），真菌如马尔尼菲塔拉酵母，和结核分枝杆菌.鉴于鉴别诊断，其中包括肿瘤，炎症，和脱髓鞘疾病，立体定向活检结合微生物学评估对于准确诊断仍有价值.
■在热带地区，当面对占位性或其他类型的脑部病变时，脑脓肿是一个值得关注的问题。脑脓肿的成功临床治疗通常结合手术干预和扩展的抗微生物治疗。然而,像查加斯病这样的特定寄生虫入侵，自由生活的变形虫,和溶组织内阿米巴需要有针对性的抗寄生虫治疗。此外，国际政策努力应侧重于风险和疾病负担增加的资源有限地区的预防措施。
■在热带气候中，易患脑脓肿的主要条件是源自鼻旁窦的多微生物细菌感染，牙科来源，和中耳炎.然而,热带地区呈现出独特的病因，包括克氏锥虫（锥虫病），像Balamuthiamandrillaris一样自由生活的变形虫，假性伯克霍尔德菌感染（类骨病），真菌如马尔尼菲塔拉酵母，和结核分枝杆菌.鉴于鉴别诊断，其中包括肿瘤，炎症，和脱髓鞘疾病，立体定向活检结合微生物学评估对于准确诊断仍有价值.
■在热带地区，当面对占位性或其他类型的脑部病变时，脑脓肿是一个值得关注的问题。脑脓肿的成功临床治疗通常结合手术干预和扩展的抗微生物治疗。然而,像查加斯病这样的特定寄生虫入侵，自由生活的变形虫,和溶组织内阿米巴需要有针对性的抗寄生虫治疗。此外，国际政策努力应侧重于风险和疾病负担增加的资源有限地区的预防措施。
