PDF(Pubmed)
Abstract：
UNASSIGNED: Chicken bones, a by-product of the poultry industry, can directly or indirectly enter the food chain. Bone meal and bone products could be sources of many contaminants. Considering the wide range of uses made of bones in the culinary and food industries, this material needs to be safe and antibiotic residue-free. To determine if such is the case, the concentration of doxycycline in chicken bones was investigated, this antimicrobial being one of the most commonly used in poultry production.
UNASSIGNED: Ross 308 broilers were grouped into three experimental and one control group. Doxycycline was administered in drinking water at therapeutic and sub-therapeutic doses, as well as via spray treatment. The concentration of doxycycline in bones was determined post slaughter by ultra-high performance liquid chromatography-tandem mass spectrometry.
UNASSIGNED: Doxycycline was quantified at 135 μg/kg 22 days after the last day of antibiotic administration at therapeutic doses; 2,285 μg/kg after sub-therapeutic treatment for 27 days and 9.62 μg/kg 22 days after the end of spray application.
UNASSIGNED: High concentrations and long persistence of doxycycline in bones were found in this study. Doxycycline can contaminate all bone-derived products in the food and fertiliser industries.
UNASSIGNED: Ross 308 broilers were grouped into three experimental and one control group. Doxycycline was administered in drinking water at therapeutic and sub-therapeutic doses, as well as via spray treatment. The concentration of doxycycline in bones was determined post slaughter by ultra-high performance liquid chromatography-tandem mass spectrometry.
UNASSIGNED: Doxycycline was quantified at 135 μg/kg 22 days after the last day of antibiotic administration at therapeutic doses; 2,285 μg/kg after sub-therapeutic treatment for 27 days and 9.62 μg/kg 22 days after the end of spray application.
UNASSIGNED: High concentrations and long persistence of doxycycline in bones were found in this study. Doxycycline can contaminate all bone-derived products in the food and fertiliser industries.
摘要：
■鸡骨头，家禽业的副产品，可以直接或间接进入食物链。骨粉和骨产品可能是许多污染物的来源。考虑到骨骼在烹饪和食品工业中的广泛用途，这种材料需要是安全和无抗生素残留的。为了确定情况是否如此，研究了强力霉素在鸡骨中的浓度，这种抗菌剂是家禽生产中最常用的一种。
■Ross308肉鸡分为三个实验组和一个对照组。多西环素在饮用水中以治疗剂量和亚治疗剂量给药，以及通过喷雾处理。用超高效液相色谱-串联质谱法测定屠宰后骨骼中多西环素的浓度。
强力霉素在治疗剂量抗生素给药最后一天后22天定量为135μg/kg；亚治疗治疗27天后为2,285μg/kg，喷雾结束后22天9.62μg/kg。
■在这项研究中发现了强力霉素在骨骼中的高浓度和长期持久性。强力霉素会污染食品和化肥行业中的所有骨骼衍生产品。
■Ross308肉鸡分为三个实验组和一个对照组。多西环素在饮用水中以治疗剂量和亚治疗剂量给药，以及通过喷雾处理。用超高效液相色谱-串联质谱法测定屠宰后骨骼中多西环素的浓度。
强力霉素在治疗剂量抗生素给药最后一天后22天定量为135μg/kg；亚治疗治疗27天后为2,285μg/kg，喷雾结束后22天9.62μg/kg。
■在这项研究中发现了强力霉素在骨骼中的高浓度和长期持久性。强力霉素会污染食品和化肥行业中的所有骨骼衍生产品。
