PDF(Pubmed)
Abstract：
In response to Dr. Yue et al\'s study on prognostic factors for post-hemihepatectomy outcomes in hepatocellular carcinoma (HCC) patients, this critical review identifies methodological limitations and proposes enhancements for future research. While the study identifies liver stiffness measure and standard residual liver volume as potential predictors, concerns regarding small sample size, reliance on biochemical markers for safety assessment, and inadequate adjustment for confounding variables are raised. Recommendations for rigorous methodology, including robust statistical analysis, consideration of confounding factors, and selection of outcome measures with clinical components, are proposed to strengthen prognostic assessments. Furthermore, validation of novel evaluation models is crucial for enhancing clinical applicability and advancing understanding of postoperative outcomes in patients with HCC undergoing hemihepatectomy.
摘要：
为了回应Yue等人对肝细胞癌（HCC）患者半肝切除术后预后因素的研究，这项关键审查确定了方法学上的局限性,并为未来的研究提出了改进建议.虽然该研究确定了肝脏硬度测量和标准剩余肝脏体积作为潜在的预测因子，关于小样本量的担忧，依赖生化标志物进行安全性评估，并提出了对混杂变量的调整不足。关于严格方法的建议，包括稳健的统计分析，考虑混杂因素，并选择具有临床成分的结果指标，建议加强预后评估。此外，新型评估模型的验证对于增强肝癌患者接受半肝切除术的临床适用性和提高对术后结局的理解至关重要.
