PDF(Pubmed)
Abstract：
UNASSIGNED: Maternal malnutrition affects the somatic growth of the fetus and subsequent adverse events during infancy and childhood period. Though trials have been conducted on multiple micronutrient (MMN) supplements initiated during the preconception period, there is no collated evidence on this.
UNASSIGNED: We performed a systematic review of published trials with the application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE). The searches were conducted until 30 September 2023. Meta-analysis was performed using Review Manager 5 software. The primary objective was to compare the effect of preconception MMN vs. iron-folic acid (IFA) supplementation on newborn anthropometric parameters at birth.
UNASSIGNED: Of the 11,832 total citations retrieved, 12 studies with data from 11,391 participants [Intervention = 5,767; Control = 5,624] were included. For the primary outcome, there was no significant difference in the birth weight [MD, 35.61 (95% CI, -7.83 to 79.06), p = 0.11], birth length [MD, 0.19 (95% CI, -0.03 to 0.42), p = 0.09], and head circumference [MD, -0.25 (95% CI, -0.64 to -0.14), p = 0.22] between the MMN and control groups. For all the secondary outcomes [except for small for gestational age (SGA) and low birth weight (LBW)], the difference between the MMN and control groups was not significant. The GRADE evidence generated for all the outcomes varied from \"very low to moderate certainty.\"
UNASSIGNED: A \"very low certainty\" of evidence suggests that MMN supplementation may not be better than routine IFA supplementation in improving newborn anthropometric parameters (weight, length, and head circumference). The adverse events resulting from the supplementation were not significant. We need better quality uniformly designed RCTs before any firm recommendation can be made.Systematic review registration: identifier (CRD42019144878: https://www.crd.york.ac.uk/prospero/#searchadvanced).
UNASSIGNED: We performed a systematic review of published trials with the application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE). The searches were conducted until 30 September 2023. Meta-analysis was performed using Review Manager 5 software. The primary objective was to compare the effect of preconception MMN vs. iron-folic acid (IFA) supplementation on newborn anthropometric parameters at birth.
UNASSIGNED: Of the 11,832 total citations retrieved, 12 studies with data from 11,391 participants [Intervention = 5,767; Control = 5,624] were included. For the primary outcome, there was no significant difference in the birth weight [MD, 35.61 (95% CI, -7.83 to 79.06), p = 0.11], birth length [MD, 0.19 (95% CI, -0.03 to 0.42), p = 0.09], and head circumference [MD, -0.25 (95% CI, -0.64 to -0.14), p = 0.22] between the MMN and control groups. For all the secondary outcomes [except for small for gestational age (SGA) and low birth weight (LBW)], the difference between the MMN and control groups was not significant. The GRADE evidence generated for all the outcomes varied from \"very low to moderate certainty.\"
UNASSIGNED: A \"very low certainty\" of evidence suggests that MMN supplementation may not be better than routine IFA supplementation in improving newborn anthropometric parameters (weight, length, and head circumference). The adverse events resulting from the supplementation were not significant. We need better quality uniformly designed RCTs before any firm recommendation can be made.Systematic review registration: identifier (CRD42019144878: https://www.crd.york.ac.uk/prospero/#searchadvanced).
摘要：
■母体营养不良会影响胎儿的身体生长以及随后在婴儿期和儿童期的不良事件。虽然已经对在孕前期间开始的多种微量营养素（MMN）补充剂进行了试验，没有整理的证据。
■我们对已发表的试验进行了系统评价，发展,和评估（等级）。搜索一直持续到2023年9月30日。采用ReviewManager5软件进行Meta分析。主要目的是比较孕前MMN与铁叶酸（IFA）补充对新生儿出生时人体测量参数的影响。
■在检索到的11,832篇引文中，包括12项研究，数据来自11,391名参与者[干预=5,767;对照=5,624]。对于主要结果，出生体重没有显着差异[MD，35.61（95%CI，-7.83至79.06），p=0.11],出生长度[MD，0.19（95%CI，-0.03至0.42），p=0.09],和头围[MD，-0.25（95%CI，-0.64至-0.14），在MMN组和对照组之间p=0.22]。对于所有次要结局[小于胎龄（SGA）和低出生体重（LBW）除外]，MMN组与对照组之间差异不显著。所有结果产生的等级证据从“非常低”到“中等”的确定性不等。\"
■A\"非常低的确定性\"证据表明，在改善新生儿人体测量参数方面，补充MMN可能不会优于常规IFA补充（体重，长度,和头围)。由补充引起的不良事件并不显著。在提出任何坚定的建议之前，我们需要更好的质量统一设计的RCT。系统审查注册：标识符（CRD42019144878：https：//www。crd.约克。AC.英国/普华永道/#searchadvanced)。
■我们对已发表的试验进行了系统评价，发展,和评估（等级）。搜索一直持续到2023年9月30日。采用ReviewManager5软件进行Meta分析。主要目的是比较孕前MMN与铁叶酸（IFA）补充对新生儿出生时人体测量参数的影响。
■在检索到的11,832篇引文中，包括12项研究，数据来自11,391名参与者[干预=5,767;对照=5,624]。对于主要结果，出生体重没有显着差异[MD，35.61（95%CI，-7.83至79.06），p=0.11],出生长度[MD，0.19（95%CI，-0.03至0.42），p=0.09],和头围[MD，-0.25（95%CI，-0.64至-0.14），在MMN组和对照组之间p=0.22]。对于所有次要结局[小于胎龄（SGA）和低出生体重（LBW）除外]，MMN组与对照组之间差异不显著。所有结果产生的等级证据从“非常低”到“中等”的确定性不等。\"
■A\"非常低的确定性\"证据表明，在改善新生儿人体测量参数方面，补充MMN可能不会优于常规IFA补充（体重，长度,和头围)。由补充引起的不良事件并不显著。在提出任何坚定的建议之前，我们需要更好的质量统一设计的RCT。系统审查注册：标识符（CRD42019144878：https：//www。crd.约克。AC.英国/普华永道/#searchadvanced)。
