PDF(Pubmed)
Abstract：
UNASSIGNED: Diet and dietary inflammation play an important role in depression. The aim of this study was to assess the association of SFAs with depression risk and the mediating role of DII.
UNASSIGNED: Among 22, 478 U.S. adults (≥ 20, years old) according to the National Health and Nutrition Examination Survey (NHANES), univariate logistic regression, and multivariate logistic regression were used to evaluate the association between dietary intake of SFAs and the risk of depression. Dietary inflammation levels were evaluated using the DII. Mediation analysis was used to investigate the risk of DII and depression. The nonlinear relationship between SFAs and depression was assessed using restricted cubic spline (RCS).
UNASSIGNED: There was a significant difference in SFA 6.0 dietary intake between depression and non-depression individuals. After adjusting for potential confounders, multifactorial logistic regression results showed that SFA 8.0 (Q3 1.58 (1.09, 2.30), p-value = 0.017; Q4 1.55 (1.00, 2.42), p-value = 0.050) may increase the prevalence factor for depression, SFA 14.0 (Q3 0.67 (0.47, 0.94), p-value = 0.020) may decrease the risk of depression. There were sex and age differences in the effects of different subtypes of SFAs on depression. Dietary intake of SFA 12.0 content showed a nonlinear relationship with the risk of depression (p-value = 0.005). Furthermore, DII was recognized as a mediator of the association between SFAs and the risk of depression.
UNASSIGNED: The findings suggest that dietary intake of SFAs is associated with the risk of depression in relation to the chain length of SFAs, and this may be due to the mediating effect of DII.
UNASSIGNED: Among 22, 478 U.S. adults (≥ 20, years old) according to the National Health and Nutrition Examination Survey (NHANES), univariate logistic regression, and multivariate logistic regression were used to evaluate the association between dietary intake of SFAs and the risk of depression. Dietary inflammation levels were evaluated using the DII. Mediation analysis was used to investigate the risk of DII and depression. The nonlinear relationship between SFAs and depression was assessed using restricted cubic spline (RCS).
UNASSIGNED: There was a significant difference in SFA 6.0 dietary intake between depression and non-depression individuals. After adjusting for potential confounders, multifactorial logistic regression results showed that SFA 8.0 (Q3 1.58 (1.09, 2.30), p-value = 0.017; Q4 1.55 (1.00, 2.42), p-value = 0.050) may increase the prevalence factor for depression, SFA 14.0 (Q3 0.67 (0.47, 0.94), p-value = 0.020) may decrease the risk of depression. There were sex and age differences in the effects of different subtypes of SFAs on depression. Dietary intake of SFA 12.0 content showed a nonlinear relationship with the risk of depression (p-value = 0.005). Furthermore, DII was recognized as a mediator of the association between SFAs and the risk of depression.
UNASSIGNED: The findings suggest that dietary intake of SFAs is associated with the risk of depression in relation to the chain length of SFAs, and this may be due to the mediating effect of DII.
摘要：
■饮食和饮食炎症在抑郁症中起重要作用。这项研究的目的是评估SFA与抑郁风险的关系以及DII的中介作用。
■根据国家健康和营养调查（NHANES），在22,478名美国成年人（≥20岁）中，单变量逻辑回归，和多因素logistic回归用于评估SFAs饮食摄入与抑郁风险之间的关系。使用DII评估饮食炎症水平。中介分析用于调查DII和抑郁的风险。使用受限三次样条（RCS）评估SFA与凹陷之间的非线性关系。
■抑郁症和非抑郁症个体之间的SFA6.0饮食摄入量存在显着差异。在调整了潜在的混杂因素后，多因素Logistic回归结果表明，SFA8.0(Q31.58(1.09，2.30)，p值=0.017；第四季度1.55（1.00，2.42），p值=0.050)可能会增加抑郁症的患病率，SFA14.0（第三季度0.67（0.47，0.94），p值=0.020）可以降低抑郁症的风险。不同亚型SFAs对抑郁症的影响存在性别和年龄差异。膳食摄入SFA12.0含量与抑郁风险呈非线性关系(p值=0.005)。此外，DII被认为是SFA与抑郁风险之间关联的中介。
■研究结果表明，SFAs的饮食摄入与SFAs链长相关的抑郁风险相关，这可能是由于DII的中介作用。
■根据国家健康和营养调查（NHANES），在22,478名美国成年人（≥20岁）中，单变量逻辑回归，和多因素logistic回归用于评估SFAs饮食摄入与抑郁风险之间的关系。使用DII评估饮食炎症水平。中介分析用于调查DII和抑郁的风险。使用受限三次样条（RCS）评估SFA与凹陷之间的非线性关系。
■抑郁症和非抑郁症个体之间的SFA6.0饮食摄入量存在显着差异。在调整了潜在的混杂因素后，多因素Logistic回归结果表明，SFA8.0(Q31.58(1.09，2.30)，p值=0.017；第四季度1.55（1.00，2.42），p值=0.050)可能会增加抑郁症的患病率，SFA14.0（第三季度0.67（0.47，0.94），p值=0.020）可以降低抑郁症的风险。不同亚型SFAs对抑郁症的影响存在性别和年龄差异。膳食摄入SFA12.0含量与抑郁风险呈非线性关系(p值=0.005)。此外，DII被认为是SFA与抑郁风险之间关联的中介。
■研究结果表明，SFAs的饮食摄入与SFAs链长相关的抑郁风险相关，这可能是由于DII的中介作用。
