Abstract：
Glycosylation is the most structurally diverse form of post-translational modification (PTM) of proteins that affects a myriad of cellular processes. As a pivotal regulator of protein homeostasis, glycosylation notably impacts the function of proteins, spanning from protein localization and stability to protein-protein interactions. Aberrant glycosylation is a hallmark of cancer, and extensive studies have revealed the multifaceted roles of glycosylation in tumor growth, migration, invasion and immune escape Over the past decade, glycosylation has emerged as an immune regulator in the tumor microenvironment (TME). Here, we summarize the intricate interplay between glycosylation and the immune system documented in recent literature, which orchestrates the regulation of the tumor immune response through endogenous lectins, immune checkpoints and the extracellular matrix (ECM) in the TME. In addition, we discuss the latest progress in glycan-based cancer immunotherapy. This review provides a basic understanding of glycosylation in the tumor immune response and a theoretical framework for tumor immunotherapy.
摘要：
糖基化是影响无数细胞过程的蛋白质的翻译后修饰(PTM)的最结构多样的形式。作为蛋白质稳态的关键调节剂，糖基化显著影响蛋白质的功能，从蛋白质定位和稳定性到蛋白质-蛋白质相互作用。糖基化异常是癌症的标志,广泛的研究揭示了糖基化在肿瘤生长中的多方面作用，迁移,入侵和免疫逃逸在过去的十年里，糖基化已成为肿瘤微环境（TME）中的免疫调节因子。这里,我们总结了最近文献中记载的糖基化和免疫系统之间复杂的相互作用，通过内源性凝集素协调肿瘤免疫反应的调节，TME中的免疫检查点和细胞外基质(ECM)。此外,我们讨论了基于聚糖的癌症免疫治疗的最新进展。这篇综述提供了对肿瘤免疫应答中糖基化的基本理解和肿瘤免疫治疗的理论框架。
