Mesh ： Humans Animals Protein Kinase Inhibitors / therapeutic use pharmacology raf Kinases / metabolism genetics Mice MAP Kinase Signaling System Mitogen-Activated Protein Kinase Kinases / metabolism Neoplasms / genetics metabolism

来  源：   DOI：10.1158/2159-8290.CD-24-0539

Abstract：
In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).
摘要：
在这个问题上，Ryan和他的同事描述了一种pan-RAF:MEK分子胶的临床前开发，大脑外显率,Ras/Raf/MAPK途径驱动肿瘤的异种移植模型的耐受性。参见Ryan等人的相关文章。,第1190页(1)。
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