Abstract：
OBJECTIVE: Tumor-infiltrating lymphocytes (TILs) represent a host-tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM.
METHODS: In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides.
RESULTS: This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease-free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group (p = 0.001), and DFS was 14 months versus 9 months (p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031).
CONCLUSIONS: Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision-making process for this group of patients.
METHODS: In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides.
RESULTS: This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease-free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group (p = 0.001), and DFS was 14 months versus 9 months (p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031).
CONCLUSIONS: Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision-making process for this group of patients.
摘要：
目的：肿瘤浸润淋巴细胞（TIL）代表宿主-肿瘤相互作用，经常表示增强的免疫反应。尽管如此，结直肠癌肝转移(CRLM)患者生存结局的影响值得严格验证.目的是证明TILs与CRLM患者生存之间的关联。
方法：在单一机构进行的回顾性评估中，我们评估了2014年至2018年间所有因CRLM而接受肝切除术的患者.执行了全面的医疗文件审查。TIL由肝脏病理学家评估，对临床信息视而不见，在所有手术幻灯片中。
结果：该回顾性队列包括112例患者。整个队列的中位总生存期（OS）为58个月，无病生存期（DFS）为12个月。组间比较显示，密集TILs组的中位OS为81个月，弱/缺失组的中位OS为40个月（p=0.001），DFS分别为14个月和9个月（p=0.041）。多变量分析显示TILs是OS的独立预测因子(HR1.95;p=0.031)。
结论：密集TILs是一个关键的预后指标，与增强型操作系统相关。在组织病理学评估中包括TIL信息应完善该组患者的临床决策过程。
方法：在单一机构进行的回顾性评估中，我们评估了2014年至2018年间所有因CRLM而接受肝切除术的患者.执行了全面的医疗文件审查。TIL由肝脏病理学家评估，对临床信息视而不见，在所有手术幻灯片中。
结果：该回顾性队列包括112例患者。整个队列的中位总生存期（OS）为58个月，无病生存期（DFS）为12个月。组间比较显示，密集TILs组的中位OS为81个月，弱/缺失组的中位OS为40个月（p=0.001），DFS分别为14个月和9个月（p=0.041）。多变量分析显示TILs是OS的独立预测因子(HR1.95;p=0.031)。
结论：密集TILs是一个关键的预后指标，与增强型操作系统相关。在组织病理学评估中包括TIL信息应完善该组患者的临床决策过程。
