Abstract：
Various forms of Parkinson\'s disease, including its common sporadic form, are characterized by prominent α-synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of αSyn, either primary or secondary, is critical for developing disease-modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
摘要：
各种形式的帕金森病,包括其常见的零星形式，其特征在于受影响的大脑区域中显著的α-突触核蛋白(αSyn)聚集。然而,αSyn在疾病的发病机制和演变中的作用尚不清楚，尽管超过四分之一世纪的大量研究工作。更好地理解αSyn的作用，主要或次要，对于开发疾病改善疗法至关重要。以前磨练这项研究的尝试受到了实验局限性的挑战，但是最近的技术进步可能会促进进步。国际帕金森与运动障碍协会（MDS）的科学问题委员会负责该领域的专家小组，以讨论当前的科学优先事项，并确定具有突破潜力的研究策略。©2024作者（S）。由WileyPeriodicalsLLC代表国际帕金森症和运动障碍协会出版的运动障碍。
