Abstract：
In this research, a novel MgSiO3 fiber membrane (MSFM) loaded with indocyanine green (ICG) and doxorubicin (DOX) was prepared. Because of MgSiO3\'s unique lamellar structure composed of a silicon-oxygen tetrahedron, magnesium ion (Mg2+) moves easily and can be further replaced with other cations. Therefore, because of the positively charged functional group of ICG, MSFM has a rather high drug loading for ICG. In addition, there is electrostatic attraction between DOX (a cationic drug) and ICG (an anionic drug). Hence, after loading ICG, more DOX can be adsorbed into MSFM because of electrostatic interaction. The ICG endows the MSFM outstanding photothermal therapy (PTT) performance, and DOX as a chemotherapeutic drug can restrain tumor growth. On the one hand, H+ exchanged with the positively charged DOX based on the MgSiO3 special lamellar structure. On the other hand, the thermal effect could break the electrostatic interaction between ICG and DOX. Based on the above two points, both tumor acidic microenvironment and photothermal effect can trigger DOX release. What\'s more, in vitro and in vivo antiosteosarcoma therapy evaluations displayed a superior synergetic PTT-chemotherapy anticancer treatment and excellent biocompatibility of DOX&ICG-MSFM. Finally, the MSFM was proven to greatly promote cell proliferation, differentiation, and bone regeneration performance in vitro and in vivo. Therefore, MSFM provides a creative perspective in the design of multifunctional scaffolds and shows promising applications in controlled drug delivery, antitumor performance, and osteogenesis.
摘要：
在这项研究中,制备了负载吲哚菁绿（ICG）和多柔比星（DOX）的新型MgSiO3纤维膜（MSFM）。由于MgSiO3的独特层状结构由硅-氧四面体组成，镁离子（Mg2+）很容易移动，可以进一步替换为其他阳离子。因此,由于ICG的带正电荷的官能团，MSFM对ICG具有相当高的载药量。此外,在DOX(阳离子药物)和ICG(阴离子药物)之间存在静电吸引。因此，加载ICG后，由于静电相互作用，更多的DOX可以吸附到MSFM中。ICG赋予MSFM出色的光热治疗（PTT）性能，而DOX作为化疗药物可以克制肿瘤的成长。一方面,基于MgSiO3特殊的层状结构，H+与带正电的DOX交换。另一方面,热效应可以破坏ICG和DOX之间的静电相互作用。基于以上两点,肿瘤酸性微环境和光热效应均可触发DOX释放。更重要的是，体外和体内抗骨肉瘤治疗评估显示出优越的协同PTT-化疗抗癌治疗和DOX和ICG-MSFM的优良生物相容性。最后,MSFM被证明可以极大地促进细胞增殖，分化,和体内外的骨再生性能。因此,MSFM在多功能支架的设计中提供了创造性的观点，并显示了在受控药物递送中的有希望的应用，抗肿瘤性能，和成骨。
