Abstract：
OBJECTIVE: This study aimed to investigate preoperative predictors of lymphovascular invasion (LVI), which is a poor prognostic factor usually detected postoperatively in patients with colorectal cancer.
METHODS: Results for all patients operated on for colorectal cancer between January 1, 2006, and December 31, 2021, were retrospectively analyzed. Potential preoperative factors and postoperative pathology results were recorded. The patients were categorized as those with LVI and those without LVI. Potential factors that may be associated with LVI were compared between the 2 groups.
RESULTS: The study included 335 patients. The incidence of LVI was 3.11 times higher in patients with ascending colon tumors (odds ratio [OR], 3.11; 95% confidence interval [CI], 1.34-7.23; P=0.008) and 4.28 times higher in those with metastatic tumors (OR, 4.28; 95% CI, 2.18-8.39; P<0.001). Diabetes mellitus was inversely related to LVI in colorectal cancer patients; specifically, LVI was 56% less common in colorectal cancer patients with diabetes mellitus, irrespective of its duration (OR, 0.44; 95% CI, 0.25-0.76; P<0.001).
UNASSIGNED: The presence of preoperative LVI in colorectal cancer patients is difficult to predict. In particular, the effect of the effect of factors such as chronic disease accompanied by microvascular pathologies on LVI is still unclear. Advances in the neoadjuvant treatment of colorectal cancer patients, who are becoming more widespread every day, will encourage the investigation of different methods of preoperatively predicting LVI as a poor prognostic factor in these patients.
METHODS: Results for all patients operated on for colorectal cancer between January 1, 2006, and December 31, 2021, were retrospectively analyzed. Potential preoperative factors and postoperative pathology results were recorded. The patients were categorized as those with LVI and those without LVI. Potential factors that may be associated with LVI were compared between the 2 groups.
RESULTS: The study included 335 patients. The incidence of LVI was 3.11 times higher in patients with ascending colon tumors (odds ratio [OR], 3.11; 95% confidence interval [CI], 1.34-7.23; P=0.008) and 4.28 times higher in those with metastatic tumors (OR, 4.28; 95% CI, 2.18-8.39; P<0.001). Diabetes mellitus was inversely related to LVI in colorectal cancer patients; specifically, LVI was 56% less common in colorectal cancer patients with diabetes mellitus, irrespective of its duration (OR, 0.44; 95% CI, 0.25-0.76; P<0.001).
UNASSIGNED: The presence of preoperative LVI in colorectal cancer patients is difficult to predict. In particular, the effect of the effect of factors such as chronic disease accompanied by microvascular pathologies on LVI is still unclear. Advances in the neoadjuvant treatment of colorectal cancer patients, who are becoming more widespread every day, will encourage the investigation of different methods of preoperatively predicting LVI as a poor prognostic factor in these patients.
摘要：
目的：本研究旨在探讨淋巴血管侵犯（LVI）的术前预测因子，这是结直肠癌患者术后常发现的不良预后因素。
方法：对2006年1月1日至2021年12月31日期间所有结直肠癌手术患者的结果进行回顾性分析。记录术前潜在因素及术后病理结果。这些患者被分类为患有LVI的患者和没有LVI的患者。比较两组之间可能与LVI相关的潜在因素。
结果：该研究包括335名患者。升结肠肿瘤患者LVI的发生率高3.11倍（比值比[OR]，3.11；95%置信区间[CI]，1.34-7.23；P=0.008）和转移性肿瘤患者的4.28倍（OR，4.28；95%CI，2.18-8.39；P<0.001）。在结直肠癌患者中，糖尿病与LVI呈负相关；特别是，在患有糖尿病的结直肠癌患者中，LVI的发生率降低了56％，无论其持续时间如何(或，0.44；95%CI，0.25-0.76；P<0.001）。
■结直肠癌患者术前LVI的存在很难预测。特别是,慢性疾病伴微血管病变等因素对LVI的影响尚不清楚。结直肠癌患者新辅助治疗的研究进展,他们每天都在变得越来越普遍，将鼓励研究不同的术前预测LVI作为这些患者的不良预后因素的方法。
方法：对2006年1月1日至2021年12月31日期间所有结直肠癌手术患者的结果进行回顾性分析。记录术前潜在因素及术后病理结果。这些患者被分类为患有LVI的患者和没有LVI的患者。比较两组之间可能与LVI相关的潜在因素。
结果：该研究包括335名患者。升结肠肿瘤患者LVI的发生率高3.11倍（比值比[OR]，3.11；95%置信区间[CI]，1.34-7.23；P=0.008）和转移性肿瘤患者的4.28倍（OR，4.28；95%CI，2.18-8.39；P<0.001）。在结直肠癌患者中，糖尿病与LVI呈负相关；特别是，在患有糖尿病的结直肠癌患者中，LVI的发生率降低了56％，无论其持续时间如何(或，0.44；95%CI，0.25-0.76；P<0.001）。
■结直肠癌患者术前LVI的存在很难预测。特别是,慢性疾病伴微血管病变等因素对LVI的影响尚不清楚。结直肠癌患者新辅助治疗的研究进展,他们每天都在变得越来越普遍，将鼓励研究不同的术前预测LVI作为这些患者的不良预后因素的方法。
