PDF(Pubmed)
Abstract：
Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer characterized by poor prognosis. The treatment requires a multidisciplinary approach, with neoadjuvant chemotherapy, surgery, and radiation therapy (RT). Particularly, high doses of conventional RT have been historically delivered in the adjuvant setting after chemotherapy and mastectomy or as radical treatment in patients ineligible for surgery. Here, we report the case of a 49-year-old woman patient with IBC unsuitable for surgery and treated with a combination of lattice RT and fractionated external beam RT concurrent with trastuzumab, with a curative aim. One year after RT, the patient showed a complete response and tolerable toxicities. This is the first reported case of a not-operable IBC patient treated with this particular kind of RT.
摘要：
炎症性乳腺癌（IBC）是一种罕见的，侵袭性乳腺癌的特点是预后不良。治疗需要多学科的方法，新辅助化疗，手术,和放射治疗（RT）。特别是,历史上,在化疗和乳房切除术后或作为不符合手术条件的患者的根治性治疗的辅助治疗中,高剂量的常规RT被给予.这里,我们报告了一例49岁女性患者的IBC不适合手术，并采用晶格RT和分割的外部束RT联合曲妥珠单抗治疗，有治愈的目的。RT后一年，患者出现完全缓解和可耐受的毒性反应.这是用这种特殊类型的RT治疗的不可手术的IBC患者的首例报道病例。
