Mesh : Humans Bronchopulmonary Dysplasia / therapy physiopathology diagnosis complications Hypertension, Pulmonary / therapy diagnosis etiology Infant, Newborn Infant, Premature Risk Factors

来  源:   DOI:10.1542/neo.25-7-e415

Abstract:
Bronchopulmonary dysplasia (BPD) is the heterogeneous chronic lung developmental disease of prematurity, which is often accompanied by multisystem comorbidities. Pulmonary vascular disease and pulmonary hypertension (PH) contribute significantly to the pathogenesis and pathophysiology of BPD and dramatically influence the outcomes of preterm infants with BPD. When caring for those patients, clinicians should consider the multitude of phenotypic presentations that fall under the \"BPD-PH umbrella,\" reflecting the need for matching therapies to specific physiologies to improve short- and long-term outcomes. Individualized management based on the patient\'s prenatal and postnatal risk factors, clinical course, and cardiopulmonary phenotype needs to be identified and prioritized to provide optimal care for infants with BPD-PH.
摘要:
支气管肺发育不良(BPD)是早产儿的异质性慢性肺发育性疾病,通常伴有多系统合并症。肺血管疾病和肺动脉高压(PH)在BPD的发病机制和病理生理学中起重要作用,并显着影响BPD早产儿的结局。在照顾那些病人时,临床医生应该考虑属于“BPD-PH保护伞下的多种表型表现,“反映了需要将疗法与特定生理相匹配,以改善短期和长期结果。根据患者的产前和产后危险因素进行个体化管理,临床课程,需要识别和优先考虑心肺表型,以便为患有BPD-PH的婴儿提供最佳护理。
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