Abstract：
The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive. VEGF expression was detected in 1 (16.7%) of 6 subjects in the ACA group and in 6 (85.7%) of 7 subjects in the ACC group. VEGF expression was not detected in any of the subjects in the control group. Endocan expression was detected in 6 (100%) of 6 subjects in the ACA group and in 7 (100%) of 7 subjects in the ACC group, while it was detected in only 4 (30.7%) of 13 subjects in the control group. VEGF was expressed with a high frequency in subjects with ACC and with a low frequency in subjects with ACA, but it was not expressed in subjects with normal adrenal cortex tissue. Although endocan was expressed with a higher frequency in subjects with ACC and ACA, it was also expressed in subjects with normal adrenal cortex tissue. The percentage of cells expressed endocan in subjects with ACC was also significantly higher than in subjects with both ACA and normal adrenal cortex.
摘要：
本研究的目的是确定血管内皮生长因子（VEGF）和endocan在肾上腺皮质肿瘤中的组织表达及其相关因素。该研究包括6名患有肾上腺皮质腺瘤（ACA）的受试者，7名患有肾上腺皮质癌（ACC）的受试者，和13名肾上腺皮质正常的对照受试者。通过在从阴性(根本没有染色)至强阳性的范围内的细胞染色比例来确定VEGF和内切酶表达的状态。在ACA组6名受试者中的1名(16.7%)和ACC组7名受试者中的6名(85.7%)中检测到VEGF表达。在对照组的任何受试者中均未检测到VEGF表达。在ACA组中的6名受试者中的6名（100％）和ACC组中的7名受试者中的7名（100％）中检测到Encan表达，而对照组13名受试者中只有4名(30.7%)检测到。VEGF在ACC受试者中表达频率高，在ACA受试者中表达频率低，但在肾上腺皮质组织正常的受试者中不表达。虽然endocan在ACC和ACA受试者中表达频率较高，在肾上腺皮质组织正常的受试者中也有表达。ACC受试者中表达内皮聚糖的细胞百分比也显着高于ACA和正常肾上腺皮质的受试者。
