Abstract：
The brain\'s choroid plexus (CP), which operates as an anatomical and functional \'checkpoint\', regulates the communication between brain and periphery and contributes to the maintenance of healthy brain homeostasis throughout life. Evidence from mouse models and humans reveals a link between loss of CP checkpoint properties and dysregulation of the CP immune milieu as a conserved feature across diverse neurological conditions. In particular, we suggest that an imbalance between different immune signals at the CP, including CD4+ T cell-derived cytokines, type-I interferon, and complement components, can perpetuate brain inflammation and cognitive deterioration in aging and neurodegeneration. Furthermore, we highlight the role of CP metabolism in controlling CP inflammation, and propose that targeting molecules that regulate CP metabolism could be effective in safeguarding brain function.
摘要：
大脑脉络丛(CP),它作为解剖学和功能性的“检查点”，调节大脑和外围之间的沟通，并有助于维持整个生命中健康的大脑稳态。来自小鼠模型和人类的证据表明，CP检查点特性的丧失与CP免疫环境的失调之间存在联系，这是各种神经系统疾病的保守特征。特别是,我们认为CP的不同免疫信号之间的不平衡，包括CD4+T细胞衍生的细胞因子，I型干扰素,和补充成分，可以在衰老和神经变性中延续大脑炎症和认知恶化。此外，我们强调了CP代谢在控制CP炎症中的作用，并提出调节CP代谢的靶向分子可以有效保护脑功能。
