Abstract：
Portal hypertension has cerebral consequences via its causes and complications, namely hepatic encephalopathy (HE), a common and devastating brain disturbance caused by liver insufficiency and portosystemic shunting. The pathogenesis involves hyperammonemia and systemic inflammation. Symptoms are disturbed personality and reduced attention. HE is minimal or grades I to IV (coma). Bouts of HE are episodic and often recurrent. Initial treatment is of events that precipitated the episode and exclusion of nonhepatic causes. Specific anti-HE treatment is lactulose. By recurrence, rifaximin is add-on. Anti-HE treatment is efficacious also for prophylaxis, but emergence of HE marks advanced liver disease and a dismal prognosis.
摘要：
门脉高压通过其原因和并发症有脑部后果，即肝性脑病（HE），由肝功能不全和门体分流引起的一种常见的破坏性脑紊乱。发病机制涉及高氨血症和全身性炎症。症状是人格紊乱和注意力减少。他是最低或I至IV级（昏迷）。HE的发作是偶发的，并且经常复发。初始治疗是指导致发作和排除非肝原因的事件。具体的抗HE治疗是乳果糖。通过复发，利福昔明是附加的。抗HE治疗对预防也有效，但是HE的出现标志着晚期肝病和预后不良。
