Abstract：
Various pathogens have the ability to grow on food matrices and instruments. This grow may reach to form biofilms. Bacterial biofilms are community of microorganisms embedded in extracellular polymeric substances (EPSs) containing lipids, DNA, proteins, and polysaccharides. These EPSs provide a tolerance and favorable living condition for microorganisms. Biofilm formations could not only contribute a risk for food safety but also have negative impacts on healthcare sector. Once biofilms form, they reveal resistances to traditional detergents and disinfectants, leading to cross-contamination. Inhibition of biofilms formation and abolition of mature biofilms is the main target for controlling of biofilm hazards in the food industry. Some novel eco-friendly technologies such as ultrasound, ultraviolet, cold plasma, magnetic nanoparticles, different chemicals additives as vitamins, D-amino acids, enzymes, antimicrobial peptides, and many other inhibitors provide a significant value on biofilm inhibition. These anti-biofilm agents represent promising tools for food industries and researchers to interfere with different phases of biofilms including adherence, quorum sensing molecules, and cell-to-cell communication. This perspective review highlights the biofilm formation mechanisms, issues associated with biofilms, environmental factors influencing bacterial biofilm development, and recent strategies employed to control biofilm-forming bacteria in the food industry. Further studies are still needed to explore the effects of biofilm regulation in food industries and exploit more regulation strategies for improving the quality and decreasing economic losses.
摘要：
各种病原体具有在食物基质和仪器上生长的能力。这种生长可以达到形成生物膜。细菌生物膜是嵌入含有脂质的细胞外聚合物质（EPS）中的微生物群落，DNA,蛋白质，和多糖。这些EPS为微生物提供了耐受性和有利的生活条件。生物膜的形成不仅会给食品安全带来风险，还会对医疗保健行业产生负面影响。一旦生物膜形成,它们显示出对传统洗涤剂和消毒剂的抗性，导致交叉污染。抑制生物膜形成和消除成熟生物膜是控制食品工业中生物膜危害的主要目标。一些新颖的环保技术，如超声波，紫外线,冷等离子体,磁性纳米粒子，不同的化学添加剂，如维生素，D-氨基酸,酶，抗菌肽，和许多其他抑制剂对生物膜抑制提供了显著的价值。这些抗生物膜剂代表了食品工业和研究人员干扰生物膜不同阶段的有前途的工具，包括粘附，群体感应分子，和细胞到细胞的通信。这篇透视综述强调了生物膜的形成机制，与生物膜相关的问题，影响细菌生物膜发育的环境因素，以及最近在食品工业中用于控制生物膜形成细菌的策略。还需要进一步的研究来探索生物膜调控在食品工业中的作用，并利用更多的调控策略来提高质量和减少经济损失。
