Abstract：
Ginsenoside, the principal active constituent of ginseng, exhibits enhanced bioavailability and medicinal efficacy in rare ginsenosides compared to major ginsenosides. Current research is focused on efficiently and selectively removing sugar groups attached to the major ginsenoside sugar chains to convert them into rare ginsenosides that meet the demands of medical industry and functional foods. The methods for preparing rare ginsenosides encompass chemical, microbial, and enzymatic approaches. Among these, the enzyme conversion method is highly favored by researchers due to its exceptional specificity and robust efficiency. This review summarizes the biological activities of different rare ginsenosides, explores the various glycosidases used in the biotransformation of different major ginsenosides as substrates, and elucidates their respective corresponding biotransformation pathways. These findings will provide valuable references for the development, utilization, and industrial production of ginsenosides.
摘要：
人参皂苷,人参的主要活性成分，与主要人参皂苷相比，稀有人参皂苷具有增强的生物利用度和药效。目前的研究集中在有效和选择性地去除连接在主要人参皂苷糖链上的糖基团，以将其转化为满足医疗工业和功能食品需求的稀有人参皂苷。制备稀有人参皂苷的方法包括化学，微生物，和酶方法。其中,酶转换方法由于其特殊的特异性和强大的效率而受到研究人员的高度青睐。本文综述了不同稀有人参皂苷的生物学活性,探索了不同主要人参皂苷作为底物的生物转化中使用的各种糖苷酶，并阐明了它们各自相应的生物转化途径。这些发现将为开发提供有价值的参考,利用率，和工业化生产人参皂苷。
