Abstract：
O-carboxymethyl chitosan (O-CMC) is a chitosan derivative produced through the substitution of hydroxyl (-OH) functional groups in glucosamine units with carboxymethyl (-CH2COOH) substituents, effectively addressing the inherent solubility issues of chitosan in aqueous solutions. O-CMC has garnered significant interest due to its enhanced solubility, elevated viscosity, minimal toxicity, and advantageous biocompatibility properties. Furthermore, O-CMC demonstrates antibacterial, antifungal, and antioxidant characteristics, rendering it a promising candidate for various biomedical uses such as wound healing, tissue engineering, anti-tumor therapies, biosensors, and bioimaging. Additionally, O-CMC is well-suited for the fabrication of nanoparticles, hydrogels, films, microcapsules, and tablets, offering opportunities for effective drug delivery systems. This review outlines the distinctive features of O-CMC, offers analyses of advancements and future potential based on current research, examines significant obstacles for clinical implementation, and foresees its ongoing significant impacts in the realm of biomedicine.
摘要：
O-羧甲基壳聚糖（O-CMC）是通过用羧甲基（-CH2COOH）取代基取代葡糖胺单元中的羟基（-OH）官能团而产生的壳聚糖衍生物，有效地解决了壳聚糖在水溶液中固有的溶解性问题。O-CMC由于其增强的溶解度而引起了人们的极大兴趣，粘度升高，最小的毒性，和有利的生物相容性。此外，O-CMC显示抗菌，抗真菌药,和抗氧化特性，使其成为各种生物医学用途的有希望的候选者，例如伤口愈合，组织工程,抗肿瘤治疗，生物传感器，和生物成像。此外,O-CMC非常适合纳米粒子的制造，水凝胶,电影,微胶囊,和药片，为有效的药物输送系统提供机会。本文概述了O-CMC的独特功能，提供基于当前研究的进步和未来潜力的分析，检查临床实施的重大障碍，并预测其在生物医学领域的持续重大影响。
