Abstract：
PtdIns and its phosphorylated derivatives, the phosphoinositides, are the biochemical components of a major pathway of intracellular signaling in all eukaryotic cells. These lipids are few in terms of cohort of unique positional isomers, and are quantitatively minor species of the bulk cellular lipidome. Nevertheless, phosphoinositides regulate an impressively diverse set of biological processes. It is from that perspective that perturbations in phosphoinositide-dependent signaling pathways are increasingly being recognized as causal foundations of many human diseases - including cancer. Although phosphatidylinositol transfer proteins (PITPs) are not enzymes, these proteins are physiologically significant regulators of phosphoinositide signaling. As such, PITPs are conserved throughout the eukaryotic kingdom. Their biological importance notwithstanding, PITPs remain understudied. Herein, we review current information regarding PITP biology primarily focusing on how derangements in PITP function disrupt key signaling/developmental pathways and are associated with a growing list of pathologies in mammals.
摘要：
PtdIns及其磷酸化衍生物，磷酸肌醇，是所有真核细胞中细胞内信号传导的主要途径的生化成分。这些脂质在独特的位置异构体队列方面很少，并且在数量上是大量细胞脂质的次要物种。然而，磷酸肌醇调节一系列不同的生物过程。从这个角度来看，磷酸肌醇依赖性信号通路的扰动越来越被认为是许多人类疾病（包括癌症）的因果基础。虽然磷脂酰肌醇转移蛋白（PITP）不是酶，这些蛋白质是磷酸肌醇信号的生理上重要的调节剂。因此，PITP在整个真核王国中是保守的。尽管它们的生物学重要性，PITPs仍未得到充分研究。在这里，我们回顾了当前有关PITP生物学的信息,主要关注PITP功能紊乱如何破坏关键信号传导/发育通路,以及与哺乳动物中越来越多的病理列表相关.
