Abstract：
OBJECTIVE: Nutrition plays a crucial role in the development and health of the human brain, from early stages to adulthood. The complex process of neurodevelopment necessitates interaction among various factors, with balance in the concentration of vital macronutrients and micronutrients being essential. Regarding micronutrients, vitamin B12 stands out, playing a vital role in the development and functioning of the motor nervous system. The objective was to investigate the influence of reduced levels of vitamin B12 on infant motor development and analyze the effects of supplementation on this aspect of development.
METHODS: For this purpose, the criteria of the PRISMA method and registration in the PROSPERO database were used. The search was conducted in the following databases: PubMed (Medline), Scopus, PsycINFO, Web of Science, and ScienceDirect. A total of 684 records were initially identified.
RESULTS: Of the eight included articles, there was diversity regarding geographical contexts and study designs. The final sample comprised a total of 1,559 participants of both sexes. Studies aimed at correcting low levels of vitamin B12 opted for supplementation, following various protocols that varied in dose, administration method, and duration. At the end of the studies, the serum level of this vitamin ranged from 131 pmol/L to 1141 pmol/L.
CONCLUSIONS: There is a complex array of factors contributing to reduced levels of vitamin B12, especially in the early stages of life, which significantly impacts infant motor development. Despite methodological variations among studies, evidence suggests that low levels of vitamin B12 may affect motor development and that supplementation could be an effective means of enhancing motor aspects in healthy children. However, due to the diversity of outcomes, it is important to promote comprehensive public policies to encourage appropriate interventions in this area.
METHODS: For this purpose, the criteria of the PRISMA method and registration in the PROSPERO database were used. The search was conducted in the following databases: PubMed (Medline), Scopus, PsycINFO, Web of Science, and ScienceDirect. A total of 684 records were initially identified.
RESULTS: Of the eight included articles, there was diversity regarding geographical contexts and study designs. The final sample comprised a total of 1,559 participants of both sexes. Studies aimed at correcting low levels of vitamin B12 opted for supplementation, following various protocols that varied in dose, administration method, and duration. At the end of the studies, the serum level of this vitamin ranged from 131 pmol/L to 1141 pmol/L.
CONCLUSIONS: There is a complex array of factors contributing to reduced levels of vitamin B12, especially in the early stages of life, which significantly impacts infant motor development. Despite methodological variations among studies, evidence suggests that low levels of vitamin B12 may affect motor development and that supplementation could be an effective means of enhancing motor aspects in healthy children. However, due to the diversity of outcomes, it is important to promote comprehensive public policies to encourage appropriate interventions in this area.
摘要：
目的：营养在人脑的发育和健康中起着至关重要的作用，从早期到成年。神经发育的复杂过程需要各种因素之间的相互作用，重要的常量营养素和微量营养素的浓度平衡是必不可少的。关于微量营养素，维生素B12脱颖而出，在运动神经系统的发育和功能中起着至关重要的作用。目的是研究维生素B12水平降低对婴儿运动发育的影响，并分析补充维生素B12对婴儿运动发育的影响。
方法：为此，使用PRISMA方法的标准和PROSPERO数据库中的注册。搜索在以下数据库中进行：PubMed(Medline)，Scopus,PsycINFO,WebofScience,和科学直接。最初总共确定了684条记录。
结果：在包含的八篇文章中，在地理环境和研究设计方面存在多样性。最终样本共包括1,559名男女参与者。旨在纠正低水平维生素B12的研究选择了补充剂，遵循剂量不同的各种方案，管理方法，和持续时间。在研究结束时,该维生素的血清水平范围为131pmol/L至1141pmol/L。
结论：有一系列复杂的因素导致维生素B12水平降低，尤其是在生命的早期阶段，这显著影响了婴儿的运动发育。尽管研究之间的方法存在差异，有证据表明，低水平的维生素B12可能会影响运动发育，补充维生素B12可能是增强健康儿童运动方面的有效手段。然而,由于结果的多样性，重要的是促进全面的公共政策，以鼓励在这一领域进行适当的干预。
方法：为此，使用PRISMA方法的标准和PROSPERO数据库中的注册。搜索在以下数据库中进行：PubMed(Medline)，Scopus,PsycINFO,WebofScience,和科学直接。最初总共确定了684条记录。
结果：在包含的八篇文章中，在地理环境和研究设计方面存在多样性。最终样本共包括1,559名男女参与者。旨在纠正低水平维生素B12的研究选择了补充剂，遵循剂量不同的各种方案，管理方法，和持续时间。在研究结束时,该维生素的血清水平范围为131pmol/L至1141pmol/L。
结论：有一系列复杂的因素导致维生素B12水平降低，尤其是在生命的早期阶段，这显著影响了婴儿的运动发育。尽管研究之间的方法存在差异，有证据表明，低水平的维生素B12可能会影响运动发育，补充维生素B12可能是增强健康儿童运动方面的有效手段。然而,由于结果的多样性，重要的是促进全面的公共政策，以鼓励在这一领域进行适当的干预。
