Abstract：
Obesity and hypothyroidism are interlinked. In this prospective study, 142 children and adolescents (mean age 140±34 months, girls 54.2%) either with obesity or overweight were included from the patients attending at the Endocrine out-patient clinic of Dhaka Shishu (Children) Hospital during a period from March, 2017 to February, 2020 and were assessed for thyroid function. Among them, 85 were obese (Body mass index, BMI >95th percentile), 29 were overweight (BMI between 85th to 95th percentile) and 28 had normal weight (BMI <85th percentile). Girls were more frequent in obese (57.6%) and overweight (51.7%) groups than boys. Mean TSH was not significantly different among the three groups (3.39 vs. 4.01 vs. 4.06mIU/L; p=0.248). Subclinical hypothyroidism was present in 22 cases (15.5%); the frequencies were 3.6% in Group 1, 17.2% in Group 2 and 18.8% in Group 3. Both overweight and obese groups had significantly (p<0.005) higher prevalence of SCH than the normal-weight group. Girls were more frequently affected than boys (72.7% vs. 27.3%, p=0.047). Among the 22 children who had SCH, 2(9.1%) had a mild goiter and higher serum levels of anti-TPO and anti-TG. Serum TSH had no correlations with age, body weight, height, BMI and serum FT₄. The findings indicate that a substantial portion of over weight and obese children and adolescents have SCH and the causes other than thyroid autoimmunity are more prevalent in them.
摘要：
肥胖和甲状腺功能减退是相互关联的。在这项前瞻性研究中，142名儿童和青少年(平均年龄140±34个月，54.2%)肥胖或超重的女孩从3月起在达卡石树(儿童)医院内分泌门诊就诊的患者中被纳入，2017年2月,2020年进行了甲状腺功能评估。其中,85人肥胖(身体质量指数，BMI>95百分位数)，29人超重（BMI在85至95百分位数之间），28人体重正常（BMI<85百分位数）。肥胖（57.6％）和超重（51.7％）组的女孩比男孩更频繁。三组之间的平均TSH没有显着差异（3.39vs.4.01vs.4.06mIU/L；p=0.248）。22例（15.5％）存在亚临床甲状腺功能减退症；组1中的频率为3.6％，组2中的频率为17.2％，组3中的频率为18.8％。超重和肥胖组的SCH患病率明显高于正常体重组（p<0.005）。女孩比男孩更容易受到影响(72.7%vs.27.3%,p=0.047)。在22名患有SCH的儿童中，2（9.1％）患有轻度甲状腺肿，抗TPO和抗TG的血清水平较高。血清TSH与年龄无关，体重,高度,BMI和血清FT。研究结果表明，超重和肥胖的儿童和青少年中有很大一部分患有SCH，除甲状腺自身免疫外，其他原因在他们中更为普遍。
