Abstract：
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease of airflow limitation that is not fully reversible. COPD affects the lungs and produces significant systemic consequences. In Bangladesh, the prevalence of COPD after 40 years of age is 21.24% and the general population is 4.3%. COPD leads to a sedentary life, which reduces the functional status of the individual. Functional status assessment is vital for appropriate therapy and rehabilitation programs in COPD patients. A Sit-to-stand test (STST) has been proposed as a better alternative to 6MWT, but a Squat-to-stand test (SqTST) to test their ability to stand from the squatting position will be more appropriate in rural patients. This study was conducted using a cross-sectional observational design from July 2020 and September 2021 in the Department of Respiratory Medicine at the National Institute of Diseases of the Chest and Hospital, Bangladesh. Sixty (60) diagnosed cases of COPD patients were enrolled in this study. Severities of airflow obstruction according to GOLD were categorized on the basis of post-bronchodilator FEV₁ by spirometry. SqTST was performed on all patients, and functional status was recorded. All data were collected using a preformed questionnaire. Statistical analyses of the findings were carried out using SPSS version 23.0. In this study, the majority of 21(35.0%) patients had very severe COPD, and almost half (48.3%) of the patients had abnormal SqTST. A significant relation was found between the severity of COPD with SqTST (p=0.001). Based on the receiver-operator characteristic (ROC) curve, SqTST had an area under curve 0.901. SqTST had 82.1% sensitivity, 85.7% specificity, 83.3% accuracy, 91.4% positive predictive value, and 72.0% negative predictive value to find severe COPD cases in stable COPD patients. ROC was constructed using SqTST, which gave a cut-off value <7.0, with 82.1% sensitivity and 85.7% specificity for predicting severe COPD. From this study, it may be concluded that SqTST is a clinically useful tool to assess the functional status of stable COPD patients.
摘要：
慢性阻塞性肺疾病（COPD）是一种可预防和可治疗的气流受限疾病，不完全可逆。COPD影响肺并产生显著的全身性后果。在孟加拉国,40岁以后COPD的患病率为21.24%,一般人群为4.3%.COPD导致久坐不动的生活，这降低了个人的功能状态。功能状态评估对于COPD患者的适当治疗和康复计划至关重要。已经提出了一种台架试验（STST）作为6MWT的更好替代方案，但下蹲试验（SqTST）来测试他们从下蹲位置站立的能力将更适合农村患者。这项研究是在2020年7月和2021年9月在美国国家胸部和医院疾病研究所呼吸内科进行的横断面观察设计。孟加拉国。本研究纳入了60(60)例确诊的COPD患者。根据肺活量测定法，根据支气管扩张剂FEV1对GOLD的气流阻塞严重程度进行了分类。对所有患者进行SqTST,并记录功能状态。使用预先形成的问卷收集所有数据。使用SPSS版本23.0对结果进行统计分析。在这项研究中,21例患者中大多数（35.0%）患有非常严重的COPD，几乎一半（48.3％）的患者SqTST异常。发现COPD严重程度与SqTST之间存在显着相关性（p=0.001）。基于接受者-操作者特征(ROC)曲线，SqTST的曲线下面积为0.901。SqTST的灵敏度为82.1%，85.7%的特异性，精度83.3%,91.4%阳性预测值，在稳定期COPD患者中发现重度COPD病例的阴性预测值为72.0%。使用SqTST构建ROC，其临界值<7.0，预测重度COPD的敏感性为82.1%，特异性为85.7%。从这项研究中,可以得出结论,SqTST是评估稳定期COPD患者功能状态的临床有用工具.
