Abstract：
Within the three-dimensional (3D) nuclear space, the genome organizes into a series of orderly structures that impose important influences on gene regulation. T lymphocytes, crucial players in adaptive immune responses, undergo intricate transcriptional remodeling upon activation, leading to differentiation into specific effector and memory T cell subsets. Recent evidence suggests that T cell activation is accompanied by dynamic changes in genome architecture at multiple levels, providing a unique biological context to explore the functional relevance and molecular mechanisms of 3D genome organization. Here, we summarize recent advances that link the reorganization of genome architecture to the remodeling of transcriptional programs and conversion of cell fates during T cell activation and differentiation. We further discuss how various chromatin architecture regulators, including CCCTC-binding factor and several transcription factors, collectively modulate the genome architecture during this process.
摘要：
在三维（3D）核空间中，基因组组织成一系列有序的结构，对基因调控产生重要影响。T淋巴细胞,适应性免疫反应的关键参与者，激活后经历复杂的转录重塑，导致分化为特异性效应和记忆T细胞亚群。最近的证据表明，T细胞活化伴随着基因组结构在多个水平上的动态变化。为探索3D基因组组织的功能相关性和分子机制提供了独特的生物学背景。这里,我们总结了最近的进展，将基因组结构的重组与转录程序的重塑以及T细胞活化和分化过程中细胞命运的转换联系起来。我们进一步讨论各种染色质结构调节剂，包括CCCTC结合因子和几种转录因子，在这个过程中共同调节基因组结构。
