Abstract：
Heart failure is an important cause of mortality and morbidity worldwide. Heart failure with preserved ejection fraction (HFpEF) incidence and prevalence is increasing, and the phenotype associated with obesity is the most frequent. Epicardial adipose tissue (EAT) is directly associated with systemic obesity and several previous studies have shown a clear link between EAT and HFpEF. Moreover, the restriction induced by the pericardium is also linked to HFpEF. In this review we will describe the epidemiological association between the pericardium, EAT and HFpEF, how to quantify EAT, what are the pathophysiological mechanism to explain theses association and how can the pericardium and EAT be a treatment target in patients with HFpEF.
摘要：
心力衰竭是全世界死亡率和发病率的重要原因。射血分数保留的心力衰竭（HFpEF）的发生率和患病率正在增加，与肥胖相关的表型是最常见的。心外膜脂肪组织（EAT）与全身性肥胖直接相关，先前的一些研究表明EAT与HFpEF之间存在明确的联系。此外，心包引起的限制也与HFpEF有关。在这篇综述中，我们将描述心包之间的流行病学关联，EAT和HFPEF，如何量化吃，解释这些关联的病理生理机制是什么，以及心包和EAT如何成为HFpEF患者的治疗目标。
