关键词: HPV cervical cancer cisplatin metal nanoparticles metal-based strategies ruthenium

来  源:   DOI:10.1016/j.drudis.2024.104073

Abstract:
Cervical cancer (CC) is one of the leading causes of death among women worldwide. The current treatments for this cancer consist of invasive methods such as chemotherapeutic drugs, radiation, immunotherapy and surgery, which could lead to severe side effects and hinder the patient\'s life quality. Although metal-based therapies, including cisplatin and ruthenium-based compounds, offer promising alternatives, they lack specificity and harm healthy cells. Combining metal nanoparticles with standard approaches has demonstrated remarkable efficacy and safety in the fight against CC. Overall, this review is intended to show the latest advancements and insights into metal-based strategies, creating a promising path for more effective and safer treatments in the battle against CC.
摘要:
宫颈癌(CC)是全球女性死亡的主要原因之一。目前这种癌症的治疗包括侵袭性方法,如化疗药物,辐射,免疫疗法和手术,这可能会导致严重的副作用,并阻碍患者的生活质量。虽然以金属为基础的疗法,包括顺铂和钌基化合物,提供有希望的替代方案,它们缺乏特异性并损害健康细胞。将金属纳米颗粒与标准方法结合在对抗CC的斗争中已经证明了显著的功效和安全性。总的来说,这篇评论旨在展示对基于金属的战略的最新进展和见解,在与CC的斗争中,为更有效和更安全的治疗创造了一条有希望的道路。
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