Abstract：
Ventricular ventricular interaction (VVI) affects blood volume and pressure in the right and left ventricles of the heart due to the location and balance of forces on the septal wall separating the ventricles. In healthy patients, the pressure of the left ventricle is considerably higher than the right, resulting in a septal wall that bows into the right ventricle. However, in patients with pulmonary hypertension, the pressure in the right ventricle increases significantly to a point where the pressure is similar to or surpasses that of the left ventricle during portions of the cardiac cycle. For these patients, the septal wall deviates towards the left ventricle, impacting its function. It is possible to study this effect using mathematical modeling, but existing models are nonlinear, leading to a system of algebraic differential equations that can be challenging to solve in patient-specific optimizations of clinical data. This study demonstrates that a simplified linearized model is sufficient to account for the effect of VVI and that, as expected, the impact is significantly more pronounced in patients with pulmonary hypertension.
摘要：
由于分隔心室的间隔壁上的力的位置和平衡，心室心室相互作用（VVI）会影响心脏右心室和左心室的血容量和压力。在健康患者中，左心室的压力比右心室高得多，导致中隔壁弯曲到右心室。然而,肺动脉高压患者，例如,右心室中的压力显著增加到在心动周期的部分期间压力类似于或超过左心室的压力的点。对于这些患者来说,间隔壁偏向左心室,影响其功能。可以使用数学建模来研究这种效应，但是现有的模型是非线性的，导致一个代数微分方程系统，在针对患者的临床数据优化中求解可能具有挑战性。这项研究表明，简化的线性化模型足以说明VVI的影响，正如预期的那样，肺动脉高压患者的影响更为明显.
