Abstract：
Fetal growth restriction and underlying placental insufficiency are associated with increased oxidative stress. Current diagnostics fail to identify all growth restricted fetuses and newborns, due to focus on small size. This scoping review aims to summarize the available evidence on usefulness of cord blood oxidative stress biomarkers for identification of growth restricted newborns in need of monitoring and support because of associated health risks. MEDLINE and EMBASE were searched from inception to May 2024. Studies were included if oxidative stress biomarkers were measured in cord blood collected immediately after delivery in newborns suspected to be growth restricted. Biomarkers were categorized based on the origin and/or biological function and their interrelationships. Oxidative stress was determined for each individual biomarker and category. Literature search identified 78 studies on 39 different biomarkers, with a total of 2707 newborns with suspected growth restriction, and 4568 controls. Total oxidant/antioxidant status, catalase, glutathione, ischemia-modified albumin, and nucleated red blood cells were most consistently associated with suspected growth restriction. Reactive oxygen species/reactive nitrogen species, factors in their production, antioxidant enzymes, non-enzymatic antioxidants, and products of oxidative stress were not consistently associated. This review collates the evidence of associations between cord blood oxidative stress biomarkers and growth restriction. Total oxidant/antioxidant status, catalase, glutathione, ischemia-modified albumin, and nucleated red blood cells could potentially be candidates for developing a cord blood diagnostic tool for future clinical use.
摘要：
胎儿生长受限和潜在的胎盘功能不全与氧化应激增加有关。目前的诊断无法识别所有生长受限的胎儿和新生儿，由于专注于小尺寸。本范围审查旨在总结脐带血氧化应激生物标志物对识别因相关健康风险而需要监测和支持的生长受限新生儿的有用性的现有证据。从开始到2024年5月，搜索了MEDLINE和EMBASE。如果在怀疑生长受限的新生儿分娩后立即收集的脐带血中测量氧化应激生物标志物，则包括研究。根据起源和/或生物学功能及其相互关系对生物标志物进行分类。确定每个个体生物标志物和类别的氧化应激。文献检索确定了39种不同生物标志物的78项研究，共有2707名新生儿怀疑生长受限，和4568个控件。总氧化剂/抗氧化剂状态，过氧化氢酶,谷胱甘肽,缺血修饰白蛋白，有核红细胞与可疑的生长受限最相关。活性氧/活性氮,他们生产中的因素，抗氧化酶，非酶抗氧化剂，和氧化应激的产物并不一致相关。这篇综述整理了脐带血氧化应激生物标志物与生长受限之间关联的证据。总氧化剂/抗氧化剂状态，过氧化氢酶,谷胱甘肽,缺血修饰白蛋白，有核红细胞有可能成为开发脐带血诊断工具的候选人，供未来临床使用。
