Abstract：
Pineal cysts are frequently encountered as incidental findings in magnetic resonance imaging, usually devoid of symptoms, yet some patients exhibit symptomatic manifestations possibly associated with the cyst, even in the absence of hydrocephalus. The etiology of these symptoms remains contentious. This study aims to investigate the presence of lymphatic endothelial cell (LEC) markers and indications of inflammation or immune response within the pineal cysts of patients experiencing symptomatic non-hydrocephalic presentations. Eight patients who underwent surgical excision of their cysts were included in the study. Immunohistochemistry was utilized to assess the expression of LYVE-1, PDPN, and VEGFR3 as LEC markers, alongside IL-6 and CD3 for indications of inflammation or immune activity. Our analysis revealed an absence of inflammatory markers or immune response. However, a distinct expression of VEGFR3 was observed, likely localized to neurons within the pineal cyst tissue. We propose that these VEGFR3+ neurons within the pineal cyst may contribute to the headache symptoms reported by these patients. Further investigations are warranted to substantiate this hypothesis.
摘要：
松果体囊肿经常作为磁共振成像中的偶然发现，通常没有症状，然而，一些患者表现出可能与囊肿相关的症状表现，即使没有脑积水.这些症状的病因仍然存在争议。这项研究旨在调查淋巴内皮细胞（LEC）标志物的存在以及有症状的非脑积水患者的松果体囊肿中炎症或免疫反应的指征。该研究包括八名接受囊肿手术切除的患者。免疫组织化学用于评估LYVE-1，PDPN，和VEGFR3作为LEC标记，与IL-6和CD3一起用于炎症或免疫活性的适应症。我们的分析显示缺乏炎症标志物或免疫反应。然而,观察到VEGFR3的不同表达，可能位于松果体囊肿组织内的神经元。我们建议松果体囊肿内的这些VEGFR3神经元可能导致这些患者报告的头痛症状。需要进一步的调查来证实这一假设。
