Abstract：
This paper is the forty-sixth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2023 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug and alcohol abuse (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
摘要：
本文是关于内源性阿片系统研究的年度选集综述的连续第46期，总结2023年发表的研究分子行为效应的文章，阿片多肽和受体的药理学和遗传操作以及阿片/阿片激动剂和拮抗剂的作用。该综述细分为以下特定主题：内源性阿片类药物及其受体的分子生化作用和神经化学定位研究（1），这些阿片类肽和受体在动物（2）和人类（3）的疼痛和镇痛中的作用，非阿片类镇痛药的阿片类敏感和阿片类不敏感作用（4），阿片类肽和受体参与耐受性和依赖性（5），压力和社会地位(6)，学习和记忆（7），吃和喝（8）吸毒和酗酒（9），性活动和荷尔蒙，怀孕,发育和内分泌学（10），精神疾病和情绪（11），癫痫发作和神经系统疾病（12），电相关活动和神经生理学(13)，一般活动和运动(14)，胃肠,肾和肝功能（15），心血管反应（16），呼吸和体温调节(17)，和免疫反应（18）。
