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Abstract：
BACKGROUND: Functional capacity impairment is a crucial consequence of chronic obstructive pulmonary disease (COPD). Although it can be identified with simple tests, such as the sit-to-stand tests, its prevalence, relation with disease severity, and the characteristics of people presenting this impairment remain unknown.
OBJECTIVE: To explore the functional capacity of people with COPD.
METHODS: A cross-sectional study with people with COPD and age-/sex-matched healthy controls was conducted. Functional capacity was assessed with the 5-repetitions (5-STS) and the 1-minute (1-minSTS) sit-to-stand tests. People with COPD were grouped according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifications. Comparisons between people with COPD and healthy controls, and among GOLD groups were established. Associations between symptoms, muscle strength, quality of life, and measures of functional capacity were explored.
RESULTS: 302 people with COPD [79% male; mean (SD) 68 (10) years old] and 304 healthy controls [75% male; 66 (9) years old] were included. 23% of people with COPD presented impairment in the 5-STS and 33% in the 1-minSTS. People with COPD from all GOLD classifications presented significantly lower functional capacity than healthy controls (5-STS: COPD median [1st quartile; 3rd quartile] 8.4 [6.7; 10.6] versus healthy 7.4 [6.2; 9.3] s; 1-minSTS: COPD 27 [21; 35] vs healthy 35 [29; 43] reps). Correlations with symptoms, muscle strength, and quality of life were mostly weak (5-STS: rs [-0.34; 0.33]; 1-minSTS: rs [-0.47; 0.40]).
CONCLUSIONS: People with COPD have decreased functional capacity independently of their GOLD classifications. The prevalence of functional impairment is 23-33%. Because impaired functional capacity is a treatable trait not accurately reflected by other outcomes, comprehensive assessment and management is needed.
OBJECTIVE: To explore the functional capacity of people with COPD.
METHODS: A cross-sectional study with people with COPD and age-/sex-matched healthy controls was conducted. Functional capacity was assessed with the 5-repetitions (5-STS) and the 1-minute (1-minSTS) sit-to-stand tests. People with COPD were grouped according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifications. Comparisons between people with COPD and healthy controls, and among GOLD groups were established. Associations between symptoms, muscle strength, quality of life, and measures of functional capacity were explored.
RESULTS: 302 people with COPD [79% male; mean (SD) 68 (10) years old] and 304 healthy controls [75% male; 66 (9) years old] were included. 23% of people with COPD presented impairment in the 5-STS and 33% in the 1-minSTS. People with COPD from all GOLD classifications presented significantly lower functional capacity than healthy controls (5-STS: COPD median [1st quartile; 3rd quartile] 8.4 [6.7; 10.6] versus healthy 7.4 [6.2; 9.3] s; 1-minSTS: COPD 27 [21; 35] vs healthy 35 [29; 43] reps). Correlations with symptoms, muscle strength, and quality of life were mostly weak (5-STS: rs [-0.34; 0.33]; 1-minSTS: rs [-0.47; 0.40]).
CONCLUSIONS: People with COPD have decreased functional capacity independently of their GOLD classifications. The prevalence of functional impairment is 23-33%. Because impaired functional capacity is a treatable trait not accurately reflected by other outcomes, comprehensive assessment and management is needed.
摘要：
背景：功能损害是慢性阻塞性肺疾病（COPD）的重要后果。虽然它可以通过简单的测试来识别，例如静坐测试，其患病率,与疾病严重程度的关系，并且呈现这种损害的人的特征仍然未知。
目的：探讨COPD患者的功能能力。
方法：对COPD患者和年龄/性别匹配的健康对照者进行横断面研究。通过5次重复（5-STS）和1分钟（1分钟STS）坐立测试来评估功能能力。COPD患者根据全球慢性阻塞性肺疾病倡议（GOLD）分类进行分组。COPD患者和健康对照者之间的比较，并在黄金集团中成立。症状之间的关联，肌肉力量,生活质量,并探讨了功能能力的衡量标准。
结果：纳入了302名COPD患者[79%男性；平均(SD)68(10)岁]和304名健康对照[75%男性；66(9)岁]。23％的COPD患者在5-STS中表现出损害，在1-minSTS中表现为33％。所有GOLD分类的COPD患者的功能能力均明显低于健康对照组（5-STS：COPD中位数[第1四分位数；第3四分位数]8.4[6.7;10.6]与健康7.4[6.2;9.3]s；1-minSTS：COPD27[21;35]与健康35[29;43]代表）。与症状相关，肌肉力量,生活质量大多较弱(5-STS:rs[-0.34;0.33];1-minSTS:rs[-0.47;0.40])。
结论：COPD患者的功能能力下降与GOLD分类无关。功能损害的患病率为23-33%。因为功能能力受损是一种可治疗的特征，不能被其他结果准确反映，需要全面的评估和管理。
目的：探讨COPD患者的功能能力。
方法：对COPD患者和年龄/性别匹配的健康对照者进行横断面研究。通过5次重复（5-STS）和1分钟（1分钟STS）坐立测试来评估功能能力。COPD患者根据全球慢性阻塞性肺疾病倡议（GOLD）分类进行分组。COPD患者和健康对照者之间的比较，并在黄金集团中成立。症状之间的关联，肌肉力量,生活质量,并探讨了功能能力的衡量标准。
结果：纳入了302名COPD患者[79%男性；平均(SD)68(10)岁]和304名健康对照[75%男性；66(9)岁]。23％的COPD患者在5-STS中表现出损害，在1-minSTS中表现为33％。所有GOLD分类的COPD患者的功能能力均明显低于健康对照组（5-STS：COPD中位数[第1四分位数；第3四分位数]8.4[6.7;10.6]与健康7.4[6.2;9.3]s；1-minSTS：COPD27[21;35]与健康35[29;43]代表）。与症状相关，肌肉力量,生活质量大多较弱(5-STS:rs[-0.34;0.33];1-minSTS:rs[-0.47;0.40])。
结论：COPD患者的功能能力下降与GOLD分类无关。功能损害的患病率为23-33%。因为功能能力受损是一种可治疗的特征，不能被其他结果准确反映，需要全面的评估和管理。
