Abstract：
UNASSIGNED: Ischemic stroke is a leading cause of morbidity and mortality worldwide. Emerging evidence suggests that left atrial (LA) dysfunction could play a role in the pathophysiology of ischemic stroke, as a possible contributor and as a predictive biomarker.
UNASSIGNED: This narrative review details the intricate relationship between LA function, atrial fibrillation (AF), and ischemic stroke. We discuss imaging techniques used to assess LA function, the mechanisms by which impaired LA function may contribute to stroke, and its potential as a prognostic marker of stroke.
UNASSIGNED: There is a lack of evidence-based treatments of LA dysfunction in both primary and secondary stroke prevention. This is partly due to the lack of a practical clinical definition and unanswered questions concerning the clinical implications of LA dysfunction in patients without AF. Until such questions are resolved, addressing well-known cardiovascular risk factors, like hypertension and obesity, should be prioritized for preventing AF and ischemic stroke. These risk factors are closely tied to atrial remodeling, emphasizing the importance of targeting primary modifiable factors for preventing future morbidity and mortality.
UNASSIGNED: This narrative review details the intricate relationship between LA function, atrial fibrillation (AF), and ischemic stroke. We discuss imaging techniques used to assess LA function, the mechanisms by which impaired LA function may contribute to stroke, and its potential as a prognostic marker of stroke.
UNASSIGNED: There is a lack of evidence-based treatments of LA dysfunction in both primary and secondary stroke prevention. This is partly due to the lack of a practical clinical definition and unanswered questions concerning the clinical implications of LA dysfunction in patients without AF. Until such questions are resolved, addressing well-known cardiovascular risk factors, like hypertension and obesity, should be prioritized for preventing AF and ischemic stroke. These risk factors are closely tied to atrial remodeling, emphasizing the importance of targeting primary modifiable factors for preventing future morbidity and mortality.
摘要：
■缺血性中风是全球发病率和死亡率的主要原因。新的证据表明，左心房（LA）功能障碍可能在缺血性卒中的病理生理学中起作用。作为可能的贡献者和预测生物标志物。
■这篇叙述性评论详细介绍了LA功能之间的复杂关系，心房颤动(AF),和缺血性中风。我们讨论了用于评估LA功能的成像技术，LA功能受损可能导致中风的机制，及其作为中风预后指标的潜力。
■在原发性和继发性中风预防中，缺乏基于证据的LA功能障碍治疗方法。部分原因是缺乏实用的临床定义，以及有关无房颤患者LA功能障碍的临床意义的未解决的问题。在这些问题得到解决之前，解决众所周知的心血管危险因素，比如高血压和肥胖，应优先预防房颤和缺血性卒中。这些危险因素与心房重构密切相关，强调针对预防未来发病率和死亡率的主要可改变因素的重要性。
■这篇叙述性评论详细介绍了LA功能之间的复杂关系，心房颤动(AF),和缺血性中风。我们讨论了用于评估LA功能的成像技术，LA功能受损可能导致中风的机制，及其作为中风预后指标的潜力。
■在原发性和继发性中风预防中，缺乏基于证据的LA功能障碍治疗方法。部分原因是缺乏实用的临床定义，以及有关无房颤患者LA功能障碍的临床意义的未解决的问题。在这些问题得到解决之前，解决众所周知的心血管危险因素，比如高血压和肥胖，应优先预防房颤和缺血性卒中。这些危险因素与心房重构密切相关，强调针对预防未来发病率和死亡率的主要可改变因素的重要性。
