Abstract：
OBJECTIVE: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissueMETHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used.
RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue.
CONCLUSIONS: The polymer\'s gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).
RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue.
CONCLUSIONS: The polymer\'s gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).
摘要：
目的：基于PluronicF127创建新的粘膜粘附剂型，然后在鼻内给药后转化为凝胶形式，用于靶向递送至脑组织方法：胞二磷胆碱，胞苷二磷酸胆碱，指定为CDP-胆碱，作为具有510.31g/mol的分子量的白色粉末购买。聚乙二醇-嵌段-聚丙二醇-嵌段-聚乙二醇(PEG-PPG-PEG)三嵌段共聚物,品牌为PluronicF127，被使用。
结果：当滴入鼻腔时，用于鼻内给药的PluronicF127转化为保持45-55分钟的凝胶，促进药物更好地渗透到脑组织中。
结论：聚合物的胶凝和粘合性能良好，这对于临床前阶段的进一步研究至关重要(标签。1，图。5，参考。28).
结果：当滴入鼻腔时，用于鼻内给药的PluronicF127转化为保持45-55分钟的凝胶，促进药物更好地渗透到脑组织中。
结论：聚合物的胶凝和粘合性能良好，这对于临床前阶段的进一步研究至关重要(标签。1，图。5，参考。28).
