Abstract：
In addition to well-known symptoms such as sleepiness and cataplexy, many people with narcolepsy have impaired cognition, reporting inattention, poor memory and other concerns. Unfortunately, research on cognition in narcolepsy has been limited. Strong evidence demonstrates difficulties with sustained attention, but evidence for executive dysfunction and impaired memory is mixed. Animal research provides some insights into how loss of the orexin neurons in narcolepsy type 1 may give rise to impaired cognition via dysfunction of the prefrontal cortex, and cholinergic and monoaminergic systems. This paper reviews some of these clinical and preclinical findings, provides a neurobiological framework to understand these deficits, and highlights some of the many key unanswered questions.
摘要：
除了众所周知的症状，如嗜睡和猝倒，许多嗜睡症患者的认知功能受损，报告注意力不集中，记忆力差和其他问题。不幸的是,关于发作性睡病认知的研究一直很有限。强有力的证据表明，持续关注有困难，但是执行功能障碍和记忆受损的证据好坏参半。动物研究提供了一些见解，以了解1型发作性睡病中食欲素神经元的丢失如何通过前额叶皮质功能障碍引起认知功能受损，以及胆碱能和单胺能系统。本文回顾了这些临床和临床前发现中的一些，提供了一个神经生物学框架来理解这些缺陷，并强调了许多关键的未回答的问题。
