Abstract：
Viral infections are one of the most common triggers of Systemic Lupus Nephritis (SLE) flare-ups. COVID-19 pneumonia can be severe in patients affected by SLE representing a risk factor for lupus nephritis flare. We report the case of a 28-year-old woman with a history of lupus nephritis (LN), who relapsed with severe nephritic-nephritic syndrome after the resolution of COVID-19 pneumonia. In addition, we conducted a literature review to analyze all described cases of LN, vaccinated and unvaccinated, in COVID-19 showing that the course of COVID-19 is more severe in SLE patients with renal involvement, especially in those who have not been vaccinated. Vaccination is the most important measure for preventing COVID-19 in people with rheumatic diseases such as SLE. The case and data we present suggests that LN relapses can occur even after the infection has resolved and illustrates the benefit of vaccination, the role of modulation of immunosuppression during COVID-19 and the specific risk of disease relapse during SARS-CoV-2 infection.
摘要：
病毒感染是系统性狼疮肾炎（SLE）发作的最常见诱因之一。COVID-19肺炎在SLE患者中可能很严重，这是狼疮性肾炎发作的危险因素。我们报告一例28岁女性，有狼疮性肾炎（LN）病史，COVID-19肺炎消退后复发，患有严重肾病-肾病综合征。此外,我们进行了文献综述，分析了所有描述的LN病例，接种疫苗和未接种疫苗，在COVID-19中显示，在有肾脏受累的SLE患者中，COVID-19的病程更严重，尤其是那些没有接种疫苗的人。疫苗接种是SLE等风湿性疾病患者预防COVID-19的最重要措施。我们提供的病例和数据表明，即使在感染解决后，LN复发也可能发生，并说明了疫苗接种的益处。COVID-19期间免疫抑制调节的作用以及SARS-CoV-2感染期间疾病复发的特定风险。
